Atkinson Richard L
Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
Int J Pediatr Obes. 2011 Sep;6 Suppl 1:2-6. doi: 10.3109/17477166.2011.590200.
There is increasing evidence that obesity in humans is associated with infection with human adenovirus-36 (Adv36). Infection of experimental animals with Adv36 demonstrates that this virus causes obesity. Human studies have shown a prevalence of Adv36 infection of 30% or greater in obese adult humans, but a correlation with obesity has not always been demonstrated. In contrast, three published studies and one presented study with a total of 559 children all show that there is an increase in prevalence of Adv36 infection in obese children (28%) compared to non-obese children (10%). The explanation for the apparently more robust correlation of Adv36 infection with obesity in children vs. adults is not clear. The data in animals and people suggests that Adv36 has contributed to the worldwide increase in childhood obesity. More research is needed to identify prevalences and consequences of Adv36 infection in people of all age groups and geographic locations.
越来越多的证据表明，人类肥胖与感染人腺病毒36型（Adv36）有关。用Adv36感染实验动物表明，这种病毒会导致肥胖。人体研究显示，肥胖成年人体内Adv36感染率达30%或更高，但肥胖与感染之间的关联并非总能得到证实。相比之下，三项已发表的研究和一项报告的研究共涉及559名儿童，所有研究均表明，与非肥胖儿童（10%）相比，肥胖儿童中Adv36感染率更高（28%）。Adv36感染与儿童肥胖之间的相关性明显强于与成人肥胖之间的相关性，原因尚不清楚。动物和人体数据表明，Adv36导致了全球儿童肥胖率的上升。需要开展更多研究，以确定所有年龄组和地理位置人群中Adv36感染的发生率及其后果。
