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合理配置还是歧视:在肾脏分配中平衡公平与效率的考虑。

Rational rationing or discrimination: balancing equity and efficiency considerations in kidney allocation.

机构信息

The Transplant Institute and Center for Transplant Outcomes and Quality Improvement at Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

出版信息

Am J Transplant. 2011 Nov;11(11):2317-21. doi: 10.1111/j.1600-6143.2011.03726.x. Epub 2011 Sep 11.

DOI:10.1111/j.1600-6143.2011.03726.x
PMID:21906253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3203330/
Abstract

After 6 years of deliberation, the Organ Procurement and Transplantation Network recently released a concept document proposing changes to the kidney allocation algorithm, sparking a heated debate about priority-setting of scarce health resources and discrimination. Proponents of the proposal argue that it will result in an additional 15,223 life years following transplant annually for recipients, yet the benefit will not be equally distributed and will likely benefit younger patients. Critics argue that the new model will promote age discrimination and may lead to a further decrease in live kidney donation. If true, these concerns could undermine fairness and damage public trust in the organ allocation system. We address these objections and consider their merit, highlighting both benefits and shortcomings of the proposal. We argue that, despite weaknesses of the proposal and the importance of maintaining consistency in patient and provider expectations over time, the proposal represents a needed first step in balancing equity and efficiency.

摘要

经过 6 年的审议,器官获取和移植网络最近发布了一份概念文件,提出了对肾脏分配算法的修改建议,引发了关于稀缺卫生资源优先配置和歧视的激烈辩论。该提案的支持者认为,这将使每年接受者的移植后预期寿命额外增加 15223 年,但受益不会均等分配,可能会使年轻患者受益。批评者认为,新模式将促进年龄歧视,并可能导致活体肾脏捐献进一步减少。如果这是真的,这些担忧可能会破坏公平性并损害公众对器官分配系统的信任。我们将解决这些反对意见,并考虑其优点,突出该提案的利弊。我们认为,尽管该提案存在弱点,而且随着时间的推移,在患者和提供者的期望方面保持一致性非常重要,但该提案代表了在平衡公平性和效率方面迈出的必要的第一步。

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本文引用的文献

1
Risk, prognosis, and unintended consequences in kidney allocation.肾脏分配中的风险、预后及意外后果。
N Engl J Med. 2011 Apr 7;364(14):1285-7. doi: 10.1056/NEJMp1102583. Epub 2011 Mar 16.
2
Improving the allocation system for deceased-donor kidneys.改善死体供肾分配系统。
N Engl J Med. 2011 Apr 7;364(14):1287-9. doi: 10.1056/NEJMp1102728. Epub 2011 Mar 16.
3
Live kidney donation: a 36-year-old woman hoping to donate a kidney to her mother.活体肾捐献:一位 36 岁的女性希望将自己的一个肾脏捐献给母亲。
JAMA. 2011 Feb 9;305(6):592-9. doi: 10.1001/jama.2011.56. Epub 2011 Jan 18.
4
Barriers to living donor kidney transplantation among black or older transplant candidates.黑人或老年移植候选人进行活体供肾移植的障碍。
Clin J Am Soc Nephrol. 2010 Dec;5(12):2338-47. doi: 10.2215/CJN.03040410. Epub 2010 Sep 28.
5
Organ donation and utilization in the United States, 1999-2008.美国 1999-2008 年的器官捐赠与利用情况。
Am J Transplant. 2010 Apr;10(4 Pt 2):973-86. doi: 10.1111/j.1600-6143.2009.03008.x.
6
Understanding disparities in transplantation: do social networks provide the missing clue?理解移植中的差异:社交网络提供了缺失的线索吗?
Am J Transplant. 2010 Mar;10(3):472-6. doi: 10.1111/j.1600-6143.2009.02963.x. Epub 2010 Jan 5.
7
Long-term consequences of kidney donation.肾脏捐献的长期后果。
N Engl J Med. 2009 Jan 29;360(5):459-69. doi: 10.1056/NEJMoa0804883.
8
Potential inefficiency of a proposed efficiency model for kidney allocation.一种提议的肾脏分配效率模型可能存在的低效性。
Am J Kidney Dis. 2008 Apr;51(4):545-8. doi: 10.1053/j.ajkd.2007.12.024.
9
Kidney and pancreas transplantation in the United States, 1997-2006: the HRSA Breakthrough Collaboratives and the 58 DSA Challenge.1997 - 2006年美国的肾脏和胰腺移植:卫生资源与服务管理局突破性合作项目及58个指定移植医院挑战
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Quality of life assessed with the Medical Outcomes Study Short Form 36-Item Health Survey of patients on renal replacement therapy: a systematic review and meta-analysis.采用医学结局研究简明健康调查36项问卷对接受肾脏替代治疗的患者进行生活质量评估:一项系统评价和荟萃分析。
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