Mouse Biology Unit, European Molecular Biology Laboratory, Via Ramarini 32, 00016 Monterotondo (Roma), Italy.
Mol Pain. 2011 Sep 11;7:66. doi: 10.1186/1744-8069-7-66.
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.
在躯体感觉领域的进展受到了研究外周感觉神经元中基因功能的可用遗传工具数量的限制。在这里，我们生成了一种 Cre 驱动小鼠品系，该品系从感觉神经元特异性基因 Advillin 的基因座表达 Cre 重组酶。这些小鼠在外周所有感觉神经元中表现出几乎完全由 Cre 介导的重组。因此，Advillin-Cre 驱动线将成为未来研究中靶向外周神经元的有力工具。
