Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan.
Epidemiol Infect. 2012 Jun;140(6):1131-40. doi: 10.1017/S0950268811001786. Epub 2011 Sep 12.
The introduction and the widespread use of the varicella vaccine in Taiwan has led to a 75-80% decrease in the incidence of varicella in children. However the vaccine's long-term impact on the incidence of herpes zoster (HZ) has attracted attention. By controlling gender, underlying diseases, and age effects, a Poisson regression was applied on the 2000-2008 chart records of 240 000 randomly selected residents who enrolled in the Universal National Health Insurance. The results show that, as the vaccine coverage in children increases, the incidence of varicella decreases. However, the incidence of HZ increased even before the implementation of the free varicella vaccination programme in 2004, particularly in females. The increase in the incidence of HZ cannot be entirely and directly attributed to the widespread vaccination of children. Continuous monitoring is needed to understand the secular trends in HZ before and after varicella vaccination in Taiwan and in other countries.
台湾引进并广泛使用水痘疫苗，已使儿童水痘发病率降低了 75%-80%。然而，疫苗对带状疱疹发病率的长期影响引起了关注。通过控制性别、基础疾病和年龄的影响，我们对 2000-2008 年 24 万随机入选全民健康保险的居民的图表记录进行了泊松回归分析。结果表明，随着儿童疫苗接种覆盖率的增加，水痘发病率下降。然而，带状疱疹发病率甚至在 2004 年免费水痘疫苗接种计划实施之前就已经上升，尤其是在女性中。带状疱疹发病率的增加不能完全且直接归因于儿童的广泛疫苗接种。需要持续监测以了解台湾和其他国家水痘疫苗接种前后带状疱疹的长期趋势。
