缺血修饰白蛋白和总同型半胱氨酸在评估 2 型糖尿病患者症状性腔隙性梗死中的作用。

Role of ischemia-modified albumin and total homocysteine in estimating symptomatic lacunar infarction in type 2 diabetic patients.

机构信息

Department of Endocrinology and Metabolism, Affiliated Huai'an Hospital of Xuzhou Medical College, No. 62 Huaihai South Road, Huai'an 223002, China.

出版信息

Clin Biochem. 2011 Nov;44(16):1299-303. doi: 10.1016/j.clinbiochem.2011.08.1136. Epub 2011 Aug 30.

DOI:10.1016/j.clinbiochem.2011.08.1136

PMID:21906585

Abstract

OBJECTIVE

To investigate whether ischemia-modified albumin (IMA) is reliable for early diagnosing symptomatic lacunar infarction (SLI) in type 2 diabetics.

DESIGN AND METHODS

Ninety-seven consecutive diabetic patients, 47 with SLI, and 45 healthy controls were enrolled. Serum IMA and plasma total homocysteine (tHcy) were measured on an autoanalyzer and evaluated in distinguishing SLI.

RESULTS

Serum IMA levels were 97.35 ± 5.25 U/L in the healthy control group, 103.26 ± 7.43 U/L in the non-SLI group, and 139.84 ± 20.00 U/L in the SLI group. Plasma tHcy levels were 8.08 ± 1.82 μmol/L, 11.31 ± 3.03 μmol/L, and 13.10 ± 3.67 μmol/L, respectively. The differences in IMA and tHcy levels were statistically significant for all groups (p<0.05). Receiver operating characteristic curve analyses revealed the areas under curve were 0.866 for IMA and 0.352 for tHcy.

CONCLUSION

This study indicates that IMA was significantly elevated in the acute phase of SLI and more sensitive than tHcy in distinguishing SLI.

摘要

目的

探讨缺血修饰白蛋白（IMA）是否可用于诊断 2 型糖尿病患者症状性腔隙性梗死（SLI）。

设计与方法

连续纳入 97 例糖尿病患者，其中 47 例为 SLI 患者，45 例为健康对照者。使用自动分析仪检测血清 IMA 和血浆总同型半胱氨酸（tHcy），并评估其在 SLI 中的鉴别诊断价值。

结果

健康对照组血清 IMA 水平为 97.35 ± 5.25 U/L，非 SLI 组为 103.26 ± 7.43 U/L，SLI 组为 139.84 ± 20.00 U/L。血浆 tHcy 水平分别为 8.08 ± 1.82 μmol/L、11.31 ± 3.03 μmol/L 和 13.10 ± 3.67 μmol/L。各组间 IMA 和 tHcy 水平差异均有统计学意义（p<0.05）。受试者工作特征曲线分析显示，IMA 的曲线下面积为 0.866，tHcy 的曲线下面积为 0.352。