Department of Psychiatry and Behavior Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
J Anxiety Disord. 2011 Dec;25(8):1139-44. doi: 10.1016/j.janxdis.2011.08.005. Epub 2011 Aug 18.
The aim of this study is to determine whether neurocognitive performance distinguishes individuals with compulsive hoarding (CH) from those with obsessive-compulsive disorder (OCD). Compared to control subjects, OCD patients and CHs scored significantly worse on the Serial Reaction Time Task suggesting disturbed implicit memory in both patient groups. On the Iowa Gambling Task, an overall learning progression difference over time was found between the CHs, OCD group, and control subjects, suggesting differences in decision-making between the groups. The groups did not differ in performance on the Stop Signal Reaction Time Task (motor inhibition). This study found evidence for impaired implicit memory in CHs, but also in OCD patients, albeit less severe. There was evidence that OCD patients learned more slowly on a decision-making task than CHs and control subjects. This latter finding provides some evidence to suggest that CH and OCD have, at least on this one measure, differing cognitive substrates.
本研究旨在确定神经认知表现是否能区分强迫囤积症（CH）患者和强迫症（OCD）患者。与对照组相比，OCD 患者和 CH 患者在连续反应时间任务上的得分明显较低，这表明这两个患者群体的内隐记忆都受到了干扰。在爱荷华赌博任务中，发现 CH 组、OCD 组和对照组之间的整体学习进度随时间存在差异，这表明组间的决策存在差异。各组在停止信号反应时间任务（运动抑制）上的表现没有差异。本研究发现 CH 患者和 OCD 患者的内隐记忆受损，尽管程度较轻。有证据表明，OCD 患者在决策任务上的学习速度比 CH 患者和对照组慢。这一发现为至少在这一测量指标上，CH 和 OCD 具有不同的认知基础提供了一些证据。
