McLaughlin Nicole C R, Kirschner Jason, Foster Hallee, O'Connell Chloe, Rasmussen Steven A, Greenberg Benjamin D
1Butler Hospital,Providence,Rhode Island.
3University of Rochester School of Medicine and Dentistry,Rochester,New York.
J Int Neuropsychol Soc. 2016 Aug;22(7):785-9. doi: 10.1017/S1355617716000540. Epub 2016 Jun 23.
Several studies have found impaired response inhibition, measured by a stop-signal task (SST), in individuals who are currently symptomatic for obsessive-compulsive disorder (OCD). The aim of this study was to assess stop-signal reaction time (SSRT) performance in individuals with a lifetime diagnosis of OCD, in comparison to a healthy control group. This is the first study that has examined OCD in participants along a continuum of OCD severity, including approximately half of whom had sub-syndromal symptoms at the time of assessment.
OCD participants were recruited primarily from within the OCD clinic at a psychiatric hospital, as well as from the community. Healthy controls were recruited from the community. We used the stop signal task to examine the difference between 21 OCD participants (mean age, 42.95 years) and 40 healthy controls (mean age, 35.13 years). We also investigated the relationship between SST and measures of OCD, depression, and anxiety severity.
OCD participants were significantly slower than healthy controls with regard to mean SSRT. Contrary to our prediction, there was no correlation between SSRT and current levels of OCD, anxiety, and depression severity.
Results support prior studies showing impaired response inhibition in OCD, and extend the findings to a sample of patients with lifetime OCD who were not all currently above threshold for diagnosis. These findings indicate that response inhibition deficits may be a biomarker of OCD, regardless of current severity levels. (JINS, 2016, 22, 785-789).
多项研究发现，采用停止信号任务（SST）测量，目前患有强迫症（OCD）的个体存在反应抑制受损的情况。本研究的目的是评估终生诊断为OCD的个体与健康对照组相比的停止信号反应时间（SSRT）表现。这是第一项沿着OCD严重程度连续体对参与者进行OCD检查的研究，其中约一半参与者在评估时具有亚综合征症状。
OCD参与者主要从一家精神病医院的OCD诊所以及社区招募。健康对照组从社区招募。我们使用停止信号任务来检查21名OCD参与者（平均年龄42.95岁）和40名健康对照组（平均年龄35.13岁）之间的差异。我们还研究了SST与OCD、抑郁和焦虑严重程度测量之间的关系。
OCD参与者的平均SSRT显著慢于健康对照组。与我们的预测相反，SSRT与当前OCD、焦虑和抑郁严重程度水平之间没有相关性。
结果支持先前的研究，表明OCD存在反应抑制受损，并将这些发现扩展到终生患有OCD的患者样本，这些患者并非目前都高于诊断阈值。这些发现表明，无论当前严重程度如何，反应抑制缺陷可能是OCD的一种生物标志物。（《神经心理疾病与治疗》，2016年，第22卷，第785 - 789页）
