Dipartimento di Patologia e Diagnostica, Sezione di Microbiologia, Università di Verona, Strada Le Grazie 8, 37134 Verona, Italy.
Curr Opin Biotechnol. 2012 Apr;23(2):160-7. doi: 10.1016/j.copbio.2011.08.006. Epub 2011 Sep 8.
Antibacterial strategies targeting bacterial adhesion to substrates are considered a valuable alternative to traditional antibiotic therapy, in view of the great advantage they bring in combating the infectious process at the very early stage without selecting for drug resistant cells. Amongst bioactive compounds with activity against bacterial adhesion, several are found in natural food and beverages, such as cranberry, tea, coffee, wine and milk. For the analysis of their anti-infective potential, successful experimental models can be conducted using different substrates from the oral cavity. Studies conducted so far in this field allowed the discovery of a variety of anti-adhesive fractions and compounds proven to be effective against bacterial traits involved in the development of oral pathologies such as caries and gingivitis/periodontitis. Discovering new anti-adhesive compounds from natural products, unravelling and testing their prophylactic and therapeutic values, and improving their use in the general population are promising new frontiers in the global fight against human infectious diseases.
针对细菌在基质上黏附的抗菌策略被认为是对抗生素治疗的一种有价值的替代方法，因为它在对抗感染过程中具有很大的优势，可以在早期阶段防止耐药细胞的产生。在具有抗细菌黏附活性的生物活性化合物中，有几种存在于天然食品和饮料中，如蔓越莓、茶、咖啡、酒和牛奶。为了分析它们的抗感染潜力，可以使用口腔中的不同基质来进行成功的实验模型。迄今为止，在这一领域进行的研究发现了多种抗黏附的成分和化合物，这些成分和化合物已被证明可有效对抗与口腔疾病（如龋齿和牙龈炎/牙周炎）发展相关的细菌特性。从天然产物中发现新的抗黏附化合物，阐明并测试其预防和治疗价值，并改善其在普通人群中的使用，是全球对抗人类传染病的一个很有前途的新领域。
