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本文引用的文献

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Neural substrates of olfactory processing in schizophrenia patients and their healthy relatives.精神分裂症患者及其健康亲属嗅觉处理的神经基质
Psychiatry Res. 2007 Jul 15;155(2):103-12. doi: 10.1016/j.pscychresns.2006.12.004. Epub 2007 May 25.
2
Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures.精神分裂症中的嗅觉功能：与临床、神经心理学及容积磁共振成像测量的关系。
J Clin Exp Neuropsychol. 2006 Nov;28(8):1444-61. doi: 10.1080/13803390500434409.
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Associations between olfactory identification and verbal memory in patients with schizophrenia, first-degree relatives, and non-psychiatric controls.精神分裂症患者、一级亲属及非精神科对照人群嗅觉识别与言语记忆之间的关联。
Schizophr Res. 2006 Sep;86(1-3):154-66. doi: 10.1016/j.schres.2006.06.007. Epub 2006 Jul 17.
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Olfactory impairment in monozygotic twins discordant for schizophrenia.精神分裂症不一致的同卵双胞胎中的嗅觉障碍。
Eur Arch Psychiatry Clin Neurosci. 2005 Apr;255(2):94-8. doi: 10.1007/s00406-004-0536-8. Epub 2004 Nov 12.
5
Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia.后来发展为精神分裂症的超高危个体的嗅觉识别能力受损。
Am J Psychiatry. 2003 Oct;160(10):1790-4. doi: 10.1176/appi.ajp.160.10.1790.
6
Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity.基于前驱症状结构化访谈对精神分裂症初始前驱期的前瞻性诊断：评分者间信度和预测效度的初步证据。
Am J Psychiatry. 2002 May;159(5):863-5. doi: 10.1176/appi.ajp.159.5.863.
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Impaired olfactory identification in relatives of patients with familial schizophrenia.家族性精神分裂症患者亲属的嗅觉识别受损。
Am J Psychiatry. 2001 Aug;158(8):1286-90. doi: 10.1176/appi.ajp.158.8.1286.
8
Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis.首发精神病且未服用过抗精神病药物患者嗅觉识别缺陷的稳定性
Am J Psychiatry. 2001 Jan;158(1):107-15. doi: 10.1176/appi.ajp.158.1.107.
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Olfactory identification deficiency and WCST performance in men with schizophrenia.
Psychiatry Res. 1998 Nov 16;81(2):251-7. doi: 10.1016/s0165-1781(98)00104-8.
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Neuropsychological, neurological and symptom correlates of impaired olfactory identification in schizophrenia.精神分裂症患者嗅觉识别受损的神经心理学、神经学及症状相关性
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有精神分裂症风险的年轻亲属的嗅觉识别能力

Olfactory identification in young relatives at risk for schizophrenia.

作者信息

Keshavan Matcheri S, Vora Anvi, Montrose Debra, Diwadkar Vaibhav A, Sweeney John

机构信息

Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.

出版信息

Acta Neuropsychiatr. 2009 Jun;21(3):121-4. doi: 10.1111/j.1601-5215.2009.00390.x.

DOI:10.1111/j.1601-5215.2009.00390.x
PMID:21909191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3169013/
Abstract

OBJECTIVE

Olfactory identification deficits (OIDs) are seen in schizophrenia, but it is unclear whether they are state- or trait-related.

METHODS

We examined the prevalence of OIDs, as assessed by the University of Pennsylvania Smell Identification Test (UPSIT), and their correlations with prodromal symptoms in young relatives at risk for schizophrenia or schizoaffective disorder (HR-S).

RESULTS

UPSIT scores were lower in HR- S than in healthy controls, but were non-significant after covarying the effects of age, gender and IQ. OID deficits in HR-S were correlated, after covarying out the effects of age and IQ, with prodromal disorganisation.

CONCLUSION

The potential value of OID deficits as markers of psychopathological vulnerability in young relatives at risk for schizophrenia deserves further investigation.

摘要

目的

精神分裂症患者存在嗅觉识别缺陷（OIDs），但尚不清楚这些缺陷是与状态相关还是与特质相关。

方法

我们通过宾夕法尼亚大学嗅觉识别测试（UPSIT）评估了嗅觉识别缺陷的患病率，并研究了其与精神分裂症或分裂情感性障碍高危年轻亲属（HR-S）前驱症状的相关性。

结果

HR-S组的UPSIT得分低于健康对照组，但在对年龄、性别和智商的影响进行协变量调整后，差异无统计学意义。在排除年龄和智商的影响后，HR-S组的嗅觉识别缺陷与前驱期的紊乱症状相关。

结论

嗅觉识别缺陷作为精神分裂症高危年轻亲属心理病理易感性标志物的潜在价值值得进一步研究。