有精神分裂症风险的年轻亲属的嗅觉识别能力
Olfactory identification in young relatives at risk for schizophrenia.
作者信息
Keshavan Matcheri S, Vora Anvi, Montrose Debra, Diwadkar Vaibhav A, Sweeney John
机构信息
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
出版信息
Acta Neuropsychiatr. 2009 Jun;21(3):121-4. doi: 10.1111/j.1601-5215.2009.00390.x.
Abstract
OBJECTIVE
Olfactory identification deficits (OIDs) are seen in schizophrenia, but it is unclear whether they are state- or trait-related.
METHODS
We examined the prevalence of OIDs, as assessed by the University of Pennsylvania Smell Identification Test (UPSIT), and their correlations with prodromal symptoms in young relatives at risk for schizophrenia or schizoaffective disorder (HR-S).
RESULTS
UPSIT scores were lower in HR- S than in healthy controls, but were non-significant after covarying the effects of age, gender and IQ. OID deficits in HR-S were correlated, after covarying out the effects of age and IQ, with prodromal disorganisation.
CONCLUSION
The potential value of OID deficits as markers of psychopathological vulnerability in young relatives at risk for schizophrenia deserves further investigation.
摘要
目的
精神分裂症患者存在嗅觉识别缺陷（OIDs），但尚不清楚这些缺陷是与状态相关还是与特质相关。
方法
我们通过宾夕法尼亚大学嗅觉识别测试（UPSIT）评估了嗅觉识别缺陷的患病率，并研究了其与精神分裂症或分裂情感性障碍高危年轻亲属（HR-S）前驱症状的相关性。
结果
HR-S组的UPSIT得分低于健康对照组，但在对年龄、性别和智商的影响进行协变量调整后，差异无统计学意义。在排除年龄和智商的影响后，HR-S组的嗅觉识别缺陷与前驱期的紊乱症状相关。
结论
嗅觉识别缺陷作为精神分裂症高危年轻亲属心理病理易感性标志物的潜在价值值得进一步研究。
相似文献
1
Olfactory identification in young relatives at risk for schizophrenia.有精神分裂症风险的年轻亲属的嗅觉识别能力
Acta Neuropsychiatr. 2009 Jun;21(3):121-4. doi: 10.1111/j.1601-5215.2009.00390.x.
2
Associations between olfactory identification and verbal memory in patients with schizophrenia, first-degree relatives, and non-psychiatric controls.精神分裂症患者、一级亲属及非精神科对照人群嗅觉识别与言语记忆之间的关联。
Schizophr Res. 2006 Sep;86(1-3):154-66. doi: 10.1016/j.schres.2006.06.007. Epub 2006 Jul 17.
3
No association between psychometrically-determined schizotypy and olfactory identification ability in first-degree relatives of patients with schizophrenia and non-psychiatric controls.在精神分裂症患者的一级亲属和非精神科对照人群中，心理测量确定的分裂型人格特质与嗅觉识别能力之间无关联。
Schizophr Res. 2008 Mar;100(1-3):216-23. doi: 10.1016/j.schres.2007.11.021. Epub 2008 Feb 20.
4
Decline of olfactory function in Parkinson's disease: A ten-year longitudinal study.帕金森病嗅觉功能减退：一项十年纵向研究。
J Parkinsons Dis. 2024 Oct 15;14(7):1877718X241298708. doi: 10.1177/1877718X241298708. Epub 2024 Nov 1.
5
Smell identification in individuals at clinical high risk for schizophrenia.精神分裂症临床高危个体的嗅觉识别
Psychiatry Res. 2014 Dec 15;220(1-2):201-4. doi: 10.1016/j.psychres.2014.07.018. Epub 2014 Jul 17.
6
Olfactory identification deficits at identification as ultra-high risk for psychosis are associated with poor functional outcome.
Schizophr Res. 2015 Feb;161(2-3):156-62. doi: 10.1016/j.schres.2014.10.051. Epub 2014 Dec 1.
7
Olfactory identification in patients with schizophrenia - the influence of β-endorphin and calcitonin gene-related peptide concentrations.精神分裂症患者的嗅觉识别——β-内啡肽和降钙素基因相关肽浓度的影响
Eur Psychiatry. 2017 Mar;41:16-20. doi: 10.1016/j.eurpsy.2016.09.004. Epub 2017 Feb 3.
8
Olfactory identification and preference in bipolar disorder and schizophrenia.双相情感障碍和精神分裂症患者的嗅觉识别和偏好。
Eur Arch Psychiatry Clin Neurosci. 2011 Jun;261(4):251-9. doi: 10.1007/s00406-010-0145-7. Epub 2010 Sep 6.
9
Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease.帕金森病中的选择性嗅觉减退和黑质纹状体多巴胺能神经支配缺失
J Neurol. 2007 Jan;254(1):84-90. doi: 10.1007/s00415-006-0284-y. Epub 2007 Feb 14.
10
Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test.精神分裂症的阴性症状与宾夕法尼亚大学嗅觉识别测试的损伤相关。
Neurosci Res. 2010 Jan;66(1):106-10. doi: 10.1016/j.neures.2009.10.001. Epub 2009 Oct 9.
引用本文的文献
1
Effects of adjunctive intranasal oxytocin on olfactory identification and clinical symptoms in schizophrenia: results from a randomized double blind placebo controlled pilot study.辅助鼻腔内给予催产素对精神分裂症患者嗅觉识别和临床症状的影响：一项随机双盲安慰剂对照的初步研究结果。
Schizophr Res. 2013 Apr;145(1-3):110-5. doi: 10.1016/j.schres.2013.01.001. Epub 2013 Feb 13.
2
The psychosis high-risk state: a comprehensive state-of-the-art review.精神病高危状态：全面的最新综述。
JAMA Psychiatry. 2013 Jan;70(1):107-20. doi: 10.1001/jamapsychiatry.2013.269.
3
An odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosis.气味特异性阈缺陷提示 cAMP 信号异常与精神病临床风险青少年有关。
Schizophr Res. 2012 Jul;138(2-3):280-4. doi: 10.1016/j.schres.2012.03.029. Epub 2012 Apr 25.
本文引用的文献
1
Neural substrates of olfactory processing in schizophrenia patients and their healthy relatives.精神分裂症患者及其健康亲属嗅觉处理的神经基质
Psychiatry Res. 2007 Jul 15;155(2):103-12. doi: 10.1016/j.pscychresns.2006.12.004. Epub 2007 May 25.
2
Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures.精神分裂症中的嗅觉功能：与临床、神经心理学及容积磁共振成像测量的关系。
J Clin Exp Neuropsychol. 2006 Nov;28(8):1444-61. doi: 10.1080/13803390500434409.
3
Associations between olfactory identification and verbal memory in patients with schizophrenia, first-degree relatives, and non-psychiatric controls.精神分裂症患者、一级亲属及非精神科对照人群嗅觉识别与言语记忆之间的关联。
Schizophr Res. 2006 Sep;86(1-3):154-66. doi: 10.1016/j.schres.2006.06.007. Epub 2006 Jul 17.
4
Olfactory impairment in monozygotic twins discordant for schizophrenia.精神分裂症不一致的同卵双胞胎中的嗅觉障碍。
Eur Arch Psychiatry Clin Neurosci. 2005 Apr;255(2):94-8. doi: 10.1007/s00406-004-0536-8. Epub 2004 Nov 12.
5
Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia.后来发展为精神分裂症的超高危个体的嗅觉识别能力受损。
Am J Psychiatry. 2003 Oct;160(10):1790-4. doi: 10.1176/appi.ajp.160.10.1790.
6
Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity.基于前驱症状结构化访谈对精神分裂症初始前驱期的前瞻性诊断：评分者间信度和预测效度的初步证据。
Am J Psychiatry. 2002 May;159(5):863-5. doi: 10.1176/appi.ajp.159.5.863.
7
Impaired olfactory identification in relatives of patients with familial schizophrenia.家族性精神分裂症患者亲属的嗅觉识别受损。
Am J Psychiatry. 2001 Aug;158(8):1286-90. doi: 10.1176/appi.ajp.158.8.1286.
8
Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis.首发精神病且未服用过抗精神病药物患者嗅觉识别缺陷的稳定性
Am J Psychiatry. 2001 Jan;158(1):107-15. doi: 10.1176/appi.ajp.158.1.107.
9
Olfactory identification deficiency and WCST performance in men with schizophrenia.
Psychiatry Res. 1998 Nov 16;81(2):251-7. doi: 10.1016/s0165-1781(98)00104-8.
10
Neuropsychological, neurological and symptom correlates of impaired olfactory identification in schizophrenia.精神分裂症患者嗅觉识别受损的神经心理学、神经学及症状相关性
Schizophr Res. 1998 Jun 22;32(1):23-30. doi: 10.1016/s0920-9964(98)00021-8.
Zotero 插件