Kumagami H, Yoshimi R
Department of Otolaryngology, Nagasaki University.
Nihon Jibiinkoka Gakkai Kaiho. 1990 Mar;93(3):407-12. doi: 10.3950/jibiinkoka.93.407.
The distribution of immunoglobulins IgG, IgA and IgM in the inner ear tissue from a patient who died of lung bleeding followed after sepsis was studied, and also the normal guinea pig inner ears and the inner ear disorders induced by Kanamycin injection were studied for the distribution of IgG. The temporal bones were fixed in formaldehyde, decalcified in EDTA and embedded in paraffin. The PAP method was used for the demonstration of the immunoglobulins. In both the human inner ear tissue and the normal control inner ear tissue of the guinea pigs deposits of IgG were found in the sensory organs and the endolymphatic sac, however, in the stria vascularis was slight. The severe damaged inner ears induced by Kanamycin the remarkable decreased deposits of IgG were found in the cochlea, but in the endolymphatic sac the remarkable increased deposits of IgG were found. No IgA and IgM were found in the human inner ear tissue.
研究了一名死于败血症后继发肺出血患者内耳组织中免疫球蛋白IgG、IgA和IgM的分布情况，还研究了正常豚鼠内耳以及卡那霉素注射诱导的内耳疾病中IgG的分布情况。颞骨用甲醛固定，用乙二胺四乙酸脱钙，然后石蜡包埋。采用过氧化物酶抗过氧化物酶（PAP）法显示免疫球蛋白。在人类内耳组织和豚鼠正常对照内耳组织中，IgG沉积物见于感觉器官和内淋巴囊，但血管纹中较少。卡那霉素诱导的严重受损内耳中，耳蜗中IgG沉积物明显减少，但内淋巴囊中IgG沉积物明显增加。在人类内耳组织中未发现IgA和IgM。
