Handa Y
Department of Internal Medicine, Oki General Hospital.
Nihon Jinzo Gakkai Shi. 1990 Feb;32(2):207-12.
Reported was an aged woman (80-year-old) of minimal change nephrotic syndrome which was complicated with reversible oliguric acute renal failure. The patient presented massive proteinuria, anasarca, and severe azotemia. She recovered conservatively from the acute renal failure and subsequently remitted from the nephrotic syndrome after the treatment which comprised albumin infusion, diuretics, adrenocorticosteroid hormones (including the pulse therapy), antiplatelet drug, and anticoagulants. The histopathologic findings of renal biopsy were compatible with minor glomerular abnormalities and acute tubular necrosis with many tubular casts. The previously reported cases older than 80-year-old which remitted from minimal change nephrotic syndrome complicated with reversible acute renal failure, were very rare. The present case was the second case among the literatures.
报告了一名80岁老年女性,患有微小病变肾病综合征,并伴有可逆性少尿性急性肾衰竭。患者出现大量蛋白尿、全身性水肿和严重氮质血症。她通过保守治疗从急性肾衰竭中康复,随后在接受包括白蛋白输注、利尿剂、肾上腺皮质类固醇激素(包括冲击疗法)、抗血小板药物和抗凝剂在内的治疗后,肾病综合征得到缓解。肾活检的组织病理学结果与轻微肾小球异常和伴有许多肾小管管型的急性肾小管坏死相符。先前报道的年龄超过80岁且从合并可逆性急性肾衰竭的微小病变肾病综合征中缓解的病例非常罕见。本病例是文献报道中的第二例。