Morita A, Ishimura E, Tabata T, Shoji S, Inoue T, Nishizawa Y, Morii H
Inoue Hospital, Osaka, Japan.
Osaka City Med J. 1994 Jul;40(1):37-42.
We report a 66-year-old man with minimal change nephrotic syndrome (MCNS) that was associated with reversible acute renal failure (ARF) caused by acute tubular necrosis (ATN). He had a subacute onset of proteinuria and progressive azotemia. Hemodialysis (HD) was required to improved azotemia. Renal biopsy revealed minor glomerular abnormalities associated with ATN. While continuing HD, steroid therapy was started, which subsequently allowed the patient to be weaned from HD and relieved from NS. In this patient, histological examination and clinical course suggested that ATN was probably induced by hypovolemia due to MCNS.
我们报告了一名66岁男性，患有微小病变肾病综合征（MCNS），该疾病与急性肾小管坏死（ATN）导致的可逆性急性肾衰竭（ARF）相关。他出现亚急性蛋白尿和进行性氮质血症。需要进行血液透析（HD）以改善氮质血症。肾活检显示与ATN相关的轻微肾小球异常。在继续进行HD的同时，开始了类固醇治疗，随后患者得以停用HD并从肾病综合征中缓解。在该患者中，组织学检查和临床过程提示ATN可能是由MCNS导致的血容量不足引起的。
