Shen Zhaomeng, Zhang Linyi, Li Zhiguo, Zhang Xian, Cui Hongbo
Lihuili hospital of Ningbo, Ningbo, China.
Eye Sci. 2011 Sep;26(3):161-5. doi: 10.3969/j.issn.1000-4432.2011.03.007.
To compare the differences in the clinical characteristics of multifocal choroiditis (MFC) and punctate inner choriodopathy (PIC).
A cross-sectional study, consisting of 22 cases (37 eyes) with MFC and 11 cases (18 eyes) with PIC, was carried out. Multiple indexes were measured and analysed to compare the differences in clinical characteristics of the subjects between two groups, including BCVA, avergae age, sex composition, presence of intraocular inflammation, choroidal neovascularization (CNV), and intraocular inflammation complications, such as cataract, cystoid macular edema (CME) and epiretinal membrane (ERM).
The average age of the MFC and PIC patients were (48.1±13.9) years and (32.1±10.2) years with a significant difference (P=0.043). CNV occurred more frequently in patients with PIC (PIC, 55.6% ;MFC, 21.6%;P=0.016) compared with those with MFC. MFC patients had a higher frequency of intraocular inflammation complications, such as, cataract (27.0%), CME(35.1%), ERM(5.4%). PIC patients presented none of these complications. MFC subjects presented with more visual impairments than PIC patients. Totally 51.4% of MFC patients had visual impairments and 22.2% of PIC patients had BCVA < 0.3 (P=0.047) .
Both MFC and PIC are categorized into the umbrella term of "white spot syndromes". Although sharing similar ocular expressions, they present with different clinical characteristics. Patients with PIC had a higher frequency of CNV but a lower frequency of structural complications caused by intraocular inflammation and lower frequency of visual impairments compared with MFC counterparts.
比较多灶性脉络膜炎（MFC）和点状内层脉络膜病变（PIC）临床特征的差异。
开展一项横断面研究，纳入22例（37只眼）MFC患者和11例（18只眼）PIC患者。测量并分析多项指标，以比较两组受试者的临床特征差异，包括最佳矫正视力（BCVA）、平均年龄、性别构成、眼内炎症情况、脉络膜新生血管（CNV）以及眼内炎症并发症，如白内障、黄斑囊样水肿（CME）和视网膜前膜（ERM）。
MFC和PIC患者的平均年龄分别为（48.1±13.9）岁和（32.1±10.2）岁，差异有统计学意义（P = 0.043）。与MFC患者相比，PIC患者中CNV的发生率更高（PIC为55.6%；MFC为21.6%；P = 0.016）。MFC患者发生眼内炎症并发症的频率更高，如白内障（27.0%）、CME（35.1%）、ERM（5.4%）。PIC患者未出现这些并发症。MFC患者的视力损害比PIC患者更多。MFC患者中共有51.4%存在视力损害，PIC患者中有22.2%的BCVA＜0.3（P = 0.047）。
MFC和PIC均归类于“白点综合征”这一统称之下。尽管有相似的眼部表现，但它们具有不同的临床特征。与MFC患者相比，PIC患者CNV发生率更高，但由眼内炎症引起的结构并发症发生率更低，视力损害发生率也更低。
