Cui Chang, Tian Ying, Zhang Lin, Wang Pei, Ding Wen-wei, Gao Yu, Wang Xiao-jin, Shi Rong, Wang Ying, Jin Jun
Department of Environmental Health, Shanghai Jiao Tong University, Shanghai 200025, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jun;45(6):494-7.
To measure the concentration of polybrominated diphenyl ethers (PBDEs) in human breast milk from a hospital in Shanghai and analyze the influencing factors.
Forty-eight puerperal from a hospital in Shanghai were selected to answer a questionnaire, and their breast milk samples were collected from September 2006 to April 2007. All the puerperal were singleton pregnancies, excluding high blood pressure, diabetes, HIV infection and adverse medical history. Seven congeners (BDE-28, BDE-47, BDE-100, BDE-99, BDE-154, BDE-153 and BDE-183) were measured by gas chromatography-negative chemical ionization-mass spectrometry and the influencing factors were analyzed.
The median of total PBDEs concentration in breast milk was 8.81 ng/g lipid weight (lw), and the range was 1.92 - 41.55 ng/g lw. The detection rates of seven congeners (BDE-28, BDE-47, BDE-100, BDE-99, BDE-154, BDE-153, BDE-183) were 98% (47/48), 96% (46/48), 86% (41/48), 90% (43/48), 83% (40/48), 98% (47/48), 90% (43/48), and the median of them was 0.88, 0.99, 0.97, 1.39, 1.14, 2.17, 1.41 ng/g lw, respectively. LogΣ(7PBDEs) in breast milk from mothers with different education levels were divided into junior high school or lower (0.89 ± 0.24), senior high school (1.02 ± 0.17), junior college or higher (1.08 ± 0.28). LogΣ(7PBDEs) in breast milk from mothers with different income levels were divided as < 1000 yuan (0.89 ± 0.12), 1000 - 3000 yuan (1.01 ± 0.24), > 3000 yuan (1.13 ± 0.21). Correlation analysis showed that both the mothers' education level (r = 0.322, P < 0.05) and income level (r = 0.388, P < 0.05) have a positive correlation to PBDEs levels in breast milk.
It is very common to detect PBDEs in human breast milk, however, the education and income levels of the mothers may be the influencing factors.
测定上海某医院人母乳中多溴二苯醚（PBDEs）的浓度，并分析其影响因素。
选取上海某医院48例产妇进行问卷调查，并于2006年9月至2007年4月采集其母乳样本。所有产妇均为单胎妊娠，排除高血压、糖尿病、HIV感染及不良病史。采用气相色谱-负化学电离-质谱法测定7种同系物（BDE-28、BDE-47、BDE-100、BDE-99、BDE-154、BDE-153和BDE-183），并分析影响因素。
母乳中总PBDEs浓度中位数为8.81 ng/g脂重（lw），范围为1.92 - 41.55 ng/g lw。7种同系物（BDE-28、BDE-47、BDE-100、BDE-99、BDE-154、BDE-153、BDE-183）的检出率分别为98%（47/48）、96%（46/48）、86%（41/48）、90%（43/48）、83%（40/48）、98%（47/48）、90%（43/48），其中位数分别为0.88、0.99、0.97、1.39、1.14、2.17、1.41 ng/g lw。不同文化程度母亲母乳中LogΣ(7PBDEs)分为初中及以下（0.89±0.24）、高中（1.02±0.17）、大专及以上（1.08±0.28）。不同收入水平母亲母乳中LogΣ(7PBDEs)分为<1000元（0.89±0.12）、1000 - 3000元（1.01±0.24）、>3000元（1.13±0.21）。相关分析表明，母亲的文化程度（r = 0.322，P < 0.05）和收入水平（r = 0.388，P < 0.05）均与母乳中PBDEs水平呈正相关。
人母乳中检测到PBDEs很常见，然而，母亲的文化程度和收入水平可能是影响因素。
