Zhang Lin, Tian Ying, Yang Xian-feng, Cui Chang, Gao Yu, Wang Xiao-jin, Wang Pei, Ding Wen-wei, Shi Rong, Wang Ying, Jin Jun, Jin Ping
Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jun;45(6):490-3.
To explore the concentration of polybrominated diphenyl ethers (PBDEs) in umbilical cord serum and analyze the influence of exposure to PBDEs during fetal stage on newborn birth outcomes in Shanghai.
Fifty delivery women in a Shanghai hospital were surveyed by questionnaire, and the umbilical cord serum were collected from September 2006 to April 2007. All the delivery women were singleton pregnancies, excluding high blood pressure, diabetes, HIV infection and adverse medical history. Seven congeners (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154 and BDE-183) were measured by gas chromatography-negative chemical ionization-mass spectrometry and the influencing factors were analyzed.
Newborns' length, weight, chest circumference, head circumference and body mass index (BMI) were (50.15 ± 0.75) cm, (3.49 ± 0.42) kg, (34.76 ± 1.51) cm, (35.03 ± 1.40) cm, (13.76 ± 1.36) kg/m(2), respectively. The median of Σ(7PBDEs) concentration in umbilical cord serum was 14.06 (1.03 - 379.73) ng/g lipid weight (lw). The detection rate of BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154 and BDE-183 were 22% (11/50), 22% (11/50), 98% (49/50), 72% (36/50), 76% (38/50), 90% (45/50) and 14% (7/50), respectively. The median (range) of PBDEs (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183) congeners were < LOD (< LOD-137.20 ng/g lw), < LOD (< LOD-33.17 ng/g lw), 7.54 ng/g lw (< LOD-94.01 ng/g lw), 1.57 ng/g lw (< LOD-46.95 ng/g lw), 0.63 ng/g lw (< LOD-79.08 ng/g lw), 0.63 ng/g lw (< LOD-22.30 ng/g lw) and < LOD (< LOD-21.63 ng/g lw), respectively. The newborns' BMI showed a negative correlation with BDE-99 (r = -0.347, P < 0.05) and BDE-154 (r = -0.292, P < 0.05). BDE-99 in low-length group (≤ 50 cm, 10.59 ng/g lw) was significantly higher (t = 2.32, P = 0.03) than that in high-length group (> 50 cm, 3.60 ng/g lw).
PBDEs were commonly detected in newborns' umbilical cord serum in this study. Our findings indicated that exposure to PBDEs adversely affected the development of the newborns.
探讨上海地区脐带血中多溴二苯醚（PBDEs）的浓度，并分析胎儿期暴露于PBDEs对新生儿出生结局的影响。
采用问卷调查法对上海某医院的50名产妇进行调查，并于2006年9月至2007年4月采集脐带血。所有产妇均为单胎妊娠，排除高血压、糖尿病、HIV感染及不良病史。采用气相色谱-负化学电离-质谱法测定7种同系物（BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154和BDE-183），并分析影响因素。
新生儿的身长、体重、胸围、头围和体重指数（BMI）分别为（50.15±0.75）cm、（3.49±0.42）kg、（34.76±1.51）cm、（35.03±1.40）cm、（13.76±1.36）kg/m²。脐带血中Σ（7种PBDEs）浓度的中位数为14.06（1.03 - 379.73）ng/g脂质重量（lw）。BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154和BDE-183的检出率分别为22%（11/50）、22%（11/�0）、98%（49/50）、72%（36/50）、76%（38/50）、90%（45/50）和14%（7/50）。PBDEs（BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183）同系物的中位数（范围）分别为<检测限（<检测限-137.20 ng/g lw）、<检测限（<检测限-33.17 ng/g lw）、7.54 ng/g lw（<检测限-94.01 ng/g lw）、1.57 ng/g lw（<检测限-46.95 ng/g lw）、0.63 ng/g lw（<检测限-79.08 ng/g lw）、0.63 ng/g lw（<检测限-22.30 ng/g lw）和<检测限（<检测限-21.63 ng/g lw）。新生儿的BMI与BDE-99（r = -0.347，P < 0.05）和BDE-154（r = -0.292，P < 0.05）呈负相关。低身长组（≤50 cm，10.59 ng/g lw）的BDE-99显著高于高身长组（>50 cm，3.60 ng/g lw）（t = 2.32，P = 0.03）。
本研究在新生儿脐带血中普遍检测到PBDEs。我们的研究结果表明，暴露于PBDEs对新生儿的发育有不利影响。
