Srinivas College of Pharmacy, Srinivas Group of College, Mangalore, Karnataka, India.
Asian Pac J Trop Med. 2011 Aug;4(8):649-53. doi: 10.1016/S1995-7645(11)60165-X.
To evaluate the anti-inflammatory and analgesic activities of the ethanol and aqueous extracts of prop roots of Pandanus fascicularis (P. fascicularis) Lam (pandanaceae). And provide experimental evidence for its traditional use such as rheumatoid arthritis and spasmodic.
The anti-inflammatory activity was observed by carrageenan-induced edema of the hind paw of rats. Analgesic activities of prop roots of P. fascicularis were determined using acetic acid induced writhing model and tail clip method in mice and rat, respectively. The ethanol fraction was then subjected to chromatographic analysis and a compound has been isolated and characterized by IR, (1)H-NMR and mass spectroscopy.
Edema suppressant effect of ethanol extract was found to be 37.03% inhibition whereas aqueous extract was found to be 63.22% inhibition after 3 h which was nearly equivalent to that of 10 mg/kg of indomethacin (67.81%). Percentage inhibition of writhing compared to control were 63.15%, 54.38%, 14.90% for aspirin, aqueous extract and ethanolic extract, respectively. Both ethanol and aqueous extracts show significant activity against appropriate controls after 60 min of treatment on tail clip method. The structure of the isolated compound is may be characterized as Hepta deca-5-ene-1-ol by analysis it's IR, (1)H-NMR and mass spectroscopy data.
The extracts of prop roots of P. fascicularis produce significant analgesic and anti-inflammatory activities, supporting the traditional application of this herb in treating various diseases associated with inflammation and pain.
评价露兜树（露兜树科）根的乙醇和水提取物的抗炎和镇痛活性。并为其传统用途（如类风湿性关节炎和痉挛）提供实验依据。
通过角叉菜胶诱导的大鼠后足肿胀观察抗炎活性。采用醋酸诱导扭体模型和小鼠、大鼠尾夹法分别测定露兜树根的镇痛活性。然后对乙醇部分进行色谱分析，通过 IR、（1）H-NMR 和质谱对分离得到的化合物进行结构鉴定。
3 h 后，乙醇提取物的抑制水肿作用为 37.03%，水提取物的抑制水肿作用为 63.22%，与吲哚美辛（67.81%）相当。与对照组相比，阿司匹林、水提物和醇提物对扭体的抑制率分别为 63.15%、54.38%和 14.90%。乙醇和水提取物在治疗 60 分钟后，在尾夹法中对合适的对照均表现出显著的活性。通过分析其 IR、（1）H-NMR 和质谱数据，分离得到的化合物的结构可能被表征为庚癸-5-烯-1-醇。
露兜树根的提取物具有显著的镇痛和抗炎活性，支持了该草药用于治疗与炎症和疼痛相关的各种疾病的传统应用。
