Department of Pharmacology, Al-Ameen College of Pharmacy, Hosur Road, Bangalore, India.
Asian Pac J Trop Med. 2011 Aug;4(8):658-60. doi: 10.1016/S1995-7645(11)60167-3.
To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in rats.
Administration of dexamethasone was given at 10 mg/kg, sc. to the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic index.
Lemongrass oil (100 and 200 mg/kg, po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg, po. The possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase (LCAT) activity.
These results suggested that Lemon gross oil possess significant anti-hyperlipidemic activity.
评价香茅油对地塞米松诱导的大鼠高血脂症的抗高血脂活性。
给成年大鼠 sc 注射地塞米松 10mg/kg，连续 8d，可诱导产生以血清胆固醇和甘油三酯水平显著升高为特征的高血脂症，并伴有动脉粥样硬化指数升高。
香茅油（100 和 200mg/kg，po.）治疗可显著抑制地塞米松引起的高血脂症，使血清胆固醇、甘油三酯和动脉粥样硬化指数接近正常水平，其抗高血脂作用与 10mg/kg po. 的阿托伐他汀相当。其可能的机制与卵磷脂胆固醇乙酰转移酶（LCAT）活性降低有关。
这些结果表明香茅油具有显著的抗高血脂活性。
