Laboratório de Genômica Funcional e Bioinformática, Pavilhão Leonidas Deane sala 104, Instituto Oswaldo Cruz, Fiocruz Av., Brasil 4365, Manguinhos, 21040-900 Rio de Janeiro, Brazil.
J Bacteriol. 2011 Oct;193(19):5600-1. doi: 10.1128/JB.05827-11.
Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. Here we report the complete genome sequence of M. bovis BCG Moreau, the strain in continuous use in Brazil for vaccine production since the 1920s.
牛分枝杆菌卡介苗(BCG)是唯一可用的结核病疫苗,全球使用的菌株代表了具有明显遗传特征的子菌株家族。在这里,我们报告了 M. bovis BCG Moreau 的完整基因组序列,该菌株自 20 世纪 20 年代以来一直在巴西连续用于疫苗生产。