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结核分枝杆菌卡介苗莫罗株基因组序列，该菌株是巴西用于结核病的疫苗株。

Genome sequence of Mycobacterium bovis BCG Moreau, the Brazilian vaccine strain against tuberculosis.

机构信息

Laboratório de Genômica Funcional e Bioinformática, Pavilhão Leonidas Deane sala 104, Instituto Oswaldo Cruz, Fiocruz Av., Brasil 4365, Manguinhos, 21040-900 Rio de Janeiro, Brazil.

出版信息

J Bacteriol. 2011 Oct;193(19):5600-1. doi: 10.1128/JB.05827-11.

DOI:10.1128/JB.05827-11
PMID:21914899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3187452/
Abstract

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. Here we report the complete genome sequence of M. bovis BCG Moreau, the strain in continuous use in Brazil for vaccine production since the 1920s.

摘要

牛分枝杆菌卡介苗（BCG）是唯一可用的结核病疫苗，全球使用的菌株代表了具有明显遗传特征的子菌株家族。在这里，我们报告了 M. bovis BCG Moreau 的完整基因组序列，该菌株自 20 世纪 20 年代以来一直在巴西连续用于疫苗生产。

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Differences in responses to the intracellular macrophage environment between Mycobacterium bovis BCG vaccine strains Moreau and Pasteur.牛型分枝杆菌卡介苗菌株 Moreau 和 Pasteur 对细胞内巨噬细胞环境反应的差异。
Mem Inst Oswaldo Cruz. 2023 Oct 13;118:e230070. doi: 10.1590/0074-02760230070. eCollection 2023.
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Impact of Genomic Deletion RD16 on the Expression of the BCG Moreau VapBC47 Toxin-Antitoxin System.基因组缺失RD16对卡介苗莫罗VapBC47毒素-抗毒素系统表达的影响
Curr Issues Mol Biol. 2023 Aug 7;45(8):6538-6549. doi: 10.3390/cimb45080412.
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本文引用的文献

1
Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur.巴西卡介苗菌株 Mycobacterium bovis BCG Moreau 与 M. bovis BCG Pasteur 培养滤液的蛋白质组图谱比较。
BMC Microbiol. 2011 Apr 20;11:80. doi: 10.1186/1471-2180-11-80.
2
Whole-genome sequences of four Mycobacterium bovis BCG vaccine strains.四种牛型分枝杆菌卡介苗菌株的全基因组序列。
J Bacteriol. 2011 Jun;193(12):3152-3. doi: 10.1128/JB.00405-11. Epub 2011 Apr 8.
3
RATT: Rapid Annotation Transfer Tool.RATT：快速注释转移工具。
Nucleic Acids Res. 2011 May;39(9):e57. doi: 10.1093/nar/gkq1268. Epub 2011 Feb 8.
4
Divergence of immunologic and protective responses of different BCG strains in a murine model.不同卡介苗菌株在小鼠模型中免疫和保护反应的差异。
Vaccine. 2011 Feb 4;29(7):1519-26. doi: 10.1016/j.vaccine.2010.12.012. Epub 2010 Dec 22.
5
Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guérin (BCG) substrains.牛分枝杆菌卡介苗（BCG）各亚菌株体外免疫刺激活性的比较研究。
FEMS Immunol Med Microbiol. 2009 Jul;56(2):116-28. doi: 10.1111/j.1574-695X.2009.00559.x. Epub 2009 Apr 27.
6
Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guérin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains.卡介苗东京172株（Mycobacterium bovis bacillus Calmette-Guérin, BCG Tokyo 172）的全基因组序列分析：卡介苗疫苗亚株的比较研究
Vaccine. 2009 Mar 10;27(11):1710-6. doi: 10.1016/j.vaccine.2009.01.034. Epub 2009 Feb 4.
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ChromaPipe: a pipeline for analysis, quality control and management for a DNA sequencing facility.ChromaPipe：一种用于DNA测序设施的分析、质量控制和管理的流程。
Genet Mol Res. 2008 Sep 23;7(3):861-71. doi: 10.4238/vol7-3x-meeting04.
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Novel genome polymorphisms in BCG vaccine strains and impact on efficacy.卡介苗疫苗株中的新型基因组多态性及其对效力的影响。
BMC Genomics. 2008 Sep 15;9:413. doi: 10.1186/1471-2164-9-413.
9
Genome plasticity of BCG and impact on vaccine efficacy.卡介苗的基因组可塑性及其对疫苗效力的影响。
Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5596-601. doi: 10.1073/pnas.0700869104. Epub 2007 Mar 19.
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BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis--review.卡介苗莫罗里约热内卢株：一种抗结核病口服疫苗——综述
Mem Inst Oswaldo Cruz. 2005 Aug;100(5):459-65. doi: 10.1590/s0074-02762005000500002. Epub 2005 Sep 15.