通过 Ugi 反应和脱硫反应合成含二氟甲基的假肽。
Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation.
机构信息
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
出版信息
Beilstein J Org Chem. 2011;7:1070-4. doi: 10.3762/bjoc.7.123. Epub 2011 Aug 8.
Abstract
Thirteen difluoromethyl-containing pseudopeptides were synthesized by Ugi reaction using the novel building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile.
摘要
十三种含二氟甲基的假肽通过 Ugi 反应合成，使用新型砌块 2,2-二氟-2-（苯硫基）乙酸（2）作为一个组分，随后在三丁基氢化锡和偶氮二异丁腈存在下除去苯硫基保护基。
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