Brehmer-Andersson E, Kaaman T, Skog E, Frithz A
Acta Derm Venereol. 1986;66(3):213-9.
Characteristics of Wells' syndrome are recurrent episodes of edema and erythema of sudden onset, often covering large areas of the skin. Microscopy shows marked eosinophilia and the presence of so-called flame figures. The flame figures have been considered to be either secondary to aggregates of expelled eosinophilic granules and disintergrating eosinophils, or foci of necrobiotic collagen. Our study indicates that the flame figure is secondary to disintegration of eosinophils and consists of aggregates of eosinophilic granules and nuclear fragments and not of necrobiotic collagen. We consider Wells' syndrome to be a distinctive clinical and histological reaction, which can be triggered by many different, mostly unknown factors.
威尔斯综合征的特征是突然发作的水肿和红斑反复发作，常累及大面积皮肤。显微镜检查显示明显的嗜酸性粒细胞增多以及所谓的火焰状图形。火焰状图形被认为要么继发于排出的嗜酸性粒细胞颗粒和嗜酸性粒细胞解体的聚集体，要么继发于坏死性胶原灶。我们的研究表明，火焰状图形继发于嗜酸性粒细胞的解体，由嗜酸性粒细胞颗粒和核碎片的聚集体组成，而非坏死性胶原。我们认为威尔斯综合征是一种独特的临床和组织学反应，可由许多不同的、大多未知的因素引发。
