The Translational Genomics Research Institute, Phoenix, AZ, USA.
Future Oncol. 2011 Sep;7(9):1045-55. doi: 10.2217/fon.11.74.
miRNAs play an important role in the regulation of a wide assortment of cellular processes by sequestering target mRNAs and inhibiting translation of the proteins that they encode. Multiple miRNAs can regulate single mRNA molecules and, alternatively, a single miRNA can act on a number of mRNA targets. Dysfunctional miRNAs are commonly found in a variety of solid cancers and are attractive candidates for next-generation therapeutics. This article highlights miRNA signatures proposed for lung cancer classification and diagnosis, chemo- and radio-therapy resistance, metastasis and prediction of treatment outcome and survival.
miRNAs 在通过隔离靶 mRNA 和抑制其编码的蛋白质翻译来调节广泛的细胞过程中起着重要作用。多个 miRNAs 可以调节单个 mRNA 分子，而相反，单个 miRNA 可以作用于多个 mRNA 靶标。功能失调的 miRNAs 通常在各种实体瘤中被发现，是下一代治疗的有吸引力的候选物。本文重点介绍了用于肺癌分类和诊断、化疗和放疗耐药性、转移以及治疗结果和生存预测的 miRNA 特征。
