正常细胞和恶性细胞的动员策略。

Mobilisation strategies for normal and malignant cells.

机构信息

Haematology, IMVS/SA Pathology and Royal Adelaide Hospital, Adelaide, Western Australia, Australia.

出版信息

Pathology. 2011 Oct;43(6):547-65. doi: 10.1097/PAT.0b013e32834a9eb8.

PMID:21921732

Abstract

This review evaluates the latest information on the mobilisation of haemopoietic stem cells for transplantation, with the focus on what is the current best practice and how new understanding of the bone marrow stem cell niche provides new insights into optimising mobilisation regimens. The review then looks at the mobilisation of mesenchymal stromal cells, immune cells as well as malignant cells and what clinical implications there are.

摘要

这篇综述评估了用于移植的造血干细胞动员的最新信息，重点介绍了当前的最佳实践，以及对骨髓干细胞龛的新认识如何为优化动员方案提供新的见解。然后，本文还探讨了间充质基质细胞、免疫细胞以及恶性细胞的动员，以及其中存在的临床意义。