Resnick J S, Sisson S, Vernier R L
Lab Invest. 1978 May;38(5):550-5.
Interstitial deposits of periodic acid-Schiff positive fibrillar material have been detected in a variety of diseases associated with tubulointerstitial pathology. This material has been shown to be Tamm-Horsfall protein by immunofluorescent, immunochemical, and electron microscopic studies. Prospective evaluation of 133 kidneys revealed deposits in 11 per cent. These deposits included medullary cystic disease (50 per cent), obstructive uropathy and vesicoureteral reflux (21 per cent), and tubulointerstitial disease (29 per cent). Tamm-Horsfall protein was also detected in Bowman's space in four cases of obstructive uropathy. It is proposed that these deposits result from severe tubular damage with release of Tamm-Horsfall protein from its normal intracellular and intralumenal locations into the renal interstitium. We speculate that the intersitial deposition of this sequestered protein may result in a continued inflammatory response and progressive renal damage.
在各种与肾小管间质病变相关的疾病中，已检测到过碘酸 - 希夫染色阳性的纤维状物质的间质沉积。通过免疫荧光、免疫化学和电子显微镜研究表明，这种物质是Tamm - Horsfall蛋白。对133个肾脏的前瞻性评估显示，11%的肾脏存在沉积物。这些沉积物包括髓质囊性疾病（50%）、梗阻性尿路病和膀胱输尿管反流（21%）以及肾小管间质疾病（29%）。在4例梗阻性尿路病患者的鲍曼间隙中也检测到了Tamm - Horsfall蛋白。有人提出，这些沉积物是由于严重的肾小管损伤，导致Tamm - Horsfall蛋白从其正常的细胞内和管腔内位置释放到肾间质中。我们推测，这种隔离蛋白的间质沉积可能导致持续的炎症反应和进行性肾损伤。
