奎尼丁硫脲催化的β-硝基膦酸酯对映选择性合成：分子筛的有益作用
Quinidine thiourea-catalyzed enantioselective synthesis of β-nitrophosphonates: Beneficial effects of molecular sieves.
作者信息
Abbaraju Santhi, Bhanushali Mayur, Zhao Cong-Gui
机构信息
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, USA.
出版信息
Tetrahedron. 2011 Sep 30;67(39):7479-7484. doi: 10.1016/j.tet.2011.07.059.
Abstract
An efficient method for enantioselective synthesis of β-nitrophosphonates via the Michael addition of diphenyl phosphite to nitroalkenes using the readily available quinidine thiourea organocatalyst has been developed. The desired β-nitrophosphonates were obtained in good ee values. Molecular sieves were found to be crucial for achieving high reproducible yields in this reaction.
摘要
已经开发出一种有效的方法，通过使用易于获得的奎尼丁硫脲有机催化剂，使亚磷酸二苯酯与硝基烯烃进行迈克尔加成反应，对映选择性合成β-硝基膦酸酯。以良好的对映体过量值获得了所需的β-硝基膦酸酯。发现分子筛对于在该反应中实现高重现性产率至关重要。
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