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使用铜催化β-酮膦酸酯的α-芳基化和脱酰基α-芳基化合成α-芳基膦酸酯

Synthesis of α-Arylphosphonates Using Copper-Catalyzed α-Arylation and Deacylative α-Arylation of β-Ketophosphonates.

作者信息

Rout Laxmidhar, Regati Sridhar, Zhao Cong-Gui

机构信息

Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.

出版信息

Adv Synth Catal. 2011 Dec 1;353(18):3340-3346. doi: 10.1002/adsc.201100605. Epub 2011 Dec 6.

DOI:10.1002/adsc.201100605
PMID:22505878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3324819/
Abstract

Efficient methods for the direct arylation and deacylative arylation of β-ketophosphonates with iodoarenes in presence of a copper(I) or a copper(II) salt as the catalysts were developed. The corresponding α-arylphosphonates were obtained in high yields. A tentative mechanism for the deacylative arylation reaction was proposed on the basis of the experimental data.

摘要

开发了在铜（I）或铜（II）盐作为催化剂存在下，β-酮膦酸酯与碘代芳烃直接芳基化和脱酰基芳基化的有效方法。以高收率得到了相应的α-芳基膦酸酯。根据实验数据提出了脱酰基芳基化反应的初步机理。

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