大肠杆菌Nus因子在转录调控及转录与翻译偶联中的作用：从结构到机制
The role of E. coli Nus-factors in transcription regulation and transcription:translation coupling: From structure to mechanism.
作者信息
Burmann Björn M, Rösch Paul
机构信息
Lehrstuhl Biopolymere und Forschungszentrum für Bio-Makromoleküle; Universität Bayreuth; Bayreuth, Germany.
出版信息
Transcription. 2011 May;2(3):130-134. doi: 10.4161/trns.2.3.15671.
Abstract
Bacterial transcription mediated by RNA polymerase (RNAP) is a highly regulated process and RNAP action is modulated during the different phases of initiation, elongation and termination by proteins such as the Escherichia coli Nus transcription-factors. Here we discuss the structural interplay and the mechanistic role of the Nus-factors that are directly involved in the processivity of elongation, transcription:translation coupling and termination, as well as the varying effects of these proteins on transcription under the influence of additional signals.
摘要
由RNA聚合酶（RNAP）介导的细菌转录是一个高度受调控的过程，在起始、延伸和终止的不同阶段，RNAP的作用会受到诸如大肠杆菌Nus转录因子等蛋白质的调节。在这里，我们讨论了直接参与延伸持续性、转录：翻译偶联和终止过程的Nus因子的结构相互作用和机制作用，以及这些蛋白质在其他信号影响下对转录的不同影响。
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