一种新型的RNA聚合酶构象揭示了转录机制。
A novel conformation of RNA polymerase sheds light on the mechanism of transcription.
作者信息
Tagami Shunsuke, Sekine Shun-Ichi, Yokoyama Shigeyuki
机构信息
RIKEN Systems and Structural Biology Center; Tsurumi, Yokohama Japan.
出版信息
Transcription. 2011 Jul;2(4):162-167. doi: 10.4161/trns.2.4.16148.
Abstract
Transcription is a complicated, multistep process requiring stringent control. Its accuracy may be achieved in part by the conformational changes of RNA polymerase (RNAP). Here, we discuss the functional relevance of the recently reported conformational changes of RNAP, which may affect transcription control, RNAP translocation and transcription termination.
摘要
转录是一个复杂的多步骤过程，需要严格的调控。其准确性部分可通过RNA聚合酶（RNAP）的构象变化来实现。在此，我们讨论最近报道的RNAP构象变化的功能相关性，这些变化可能影响转录调控、RNAP易位和转录终止。
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