改变辅助性T细胞的现状。
Changing the STATus quo in T helper cells.
作者信息
Stritesky Gretta L, Kaplan Mark H
机构信息
Department of Lab Medicine and Pathology; Center for Immunology; University of Minnesota; Minneapolis, MN USA.
出版信息
Transcription. 2011 Jul;2(4):179-182. doi: 10.4161/trns.2.4.16614.
Abstract
STAT proteins are obligate promoters of T helper cell differentiation and initial studies suggested that activation of a single STAT protein resulted in a particular phenotype. More recent work has supported a more complex paradigm wherein the activation of several STAT proteins is required for differentiation to a single effector lineage.
摘要
信号转导和转录激活因子（STAT）蛋白是T辅助细胞分化的必需促进因子，早期研究表明，单一STAT蛋白的激活会导致特定的表型。最近的研究支持了一种更复杂的模式，即分化为单一效应细胞谱系需要几种STAT蛋白的激活。
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