Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), 133 207, Mullana- Ambala, Haryana, India.
NGO Praeventio, 50407, Tartu, Estonia.
Mol Biol Rep. 2022 Sep;49(9):8987-8999. doi: 10.1007/s11033-022-07399-w. Epub 2022 Apr 26.
As a landmark, scientific investigation in cytokine signaling and interferon-related anti-viral activity, signal transducer and activator of transcription (STAT) family of proteins was first discovered in the 1990s. Today, we know that the STAT family consists of several transcription factors which regulate various molecular and cellular processes, including proliferation, angiogenesis, and differentiation in human carcinoma. STAT family members play an active role in transducing signals from cell membrane to nucleus through intracellular signaling and thus activating gene transcription. Additionally, they are also associated with the development and progression of human cancer by facilitating inflammation, cell survival, and resistance to therapeutic responses. Accumulating evidence suggests that not all STAT proteins are associated with the progression of human malignancy; however, STAT3/5 are constitutively activated in various cancers, including multiple myeloma, lymphoma, breast cancer, prostate hepatocellular carcinoma, and non-small cell lung cancer. The present review highlights how STAT-associated events are implicated in cancer inflammation, angiogenesis and non-coding RNA (ncRNA) modulation to highlight potential intervention into carcinogenesis-related cellular processes.
作为细胞因子信号转导和干扰素相关抗病毒活性的标志性科学研究，信号转导子和转录激活子（STAT）家族蛋白于 20 世纪 90 年代首次被发现。如今，我们知道 STAT 家族由几种转录因子组成，它们调节包括人类癌中的增殖、血管生成和分化在内的各种分子和细胞过程。STAT 家族成员通过细胞内信号转导在将信号从细胞膜转导到细胞核中发挥积极作用，从而激活基因转录。此外，它们还通过促进炎症、细胞存活和对治疗反应的抵抗力，与人类癌症的发生和进展相关。越来越多的证据表明，并非所有 STAT 蛋白都与人类恶性肿瘤的进展有关；然而，STAT3/5 在多种癌症中持续激活，包括多发性骨髓瘤、淋巴瘤、乳腺癌、前列腺癌、肝癌和非小细胞肺癌。本综述强调了 STAT 相关事件如何参与癌症炎症、血管生成和非编码 RNA（ncRNA）调节，以突出可能干预与致癌作用相关的细胞过程。
