Ejaz Shakir M, Khawaja Imran S, Bhatia Subhash, Hurwitz Thomas D
Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, Minneapolis, Minnesota, USA.
Innov Clin Neurosci. 2011 Aug;8(8):17-25.
Obstructive sleep apnea is a common sleep disorder associated with several medical conditions, increased risk of motor vehicle accidents, and overall healthcare expenditure. There is higher prevalence of depression in people with obstructive sleep apnea in both clinical and community samples. Many symptoms of depression and obstructive sleep apnea overlap causing under-diagnosis of obstructive sleep apnea in depressed patients. Sleep problems, including obstructive sleep apnea, are rarely assessed on a regular basis in patients with depressive disorders, but they may be responsible for antidepressant treatment failure. The mechanism of the relationship between obstructive sleep apnea and depression is complex and remains unclear. Though some studies suggest a mutual relationship, the relationship remains unclear. Several possible pathophysiological mechanisms could explain how obstructive sleep apnea can cause or worsen depression. Increased knowledge of the relationship between obstructive sleep apnea and depression might significantly improve diagnostic accuracy as well as treatment outcomes for both obstructive sleep apnea and depression.
阻塞性睡眠呼吸暂停是一种常见的睡眠障碍，与多种医疗状况、机动车事故风险增加以及总体医疗保健支出相关。在临床和社区样本中，阻塞性睡眠呼吸暂停患者中抑郁症的患病率更高。抑郁症和阻塞性睡眠呼吸暂停的许多症状重叠，导致抑郁症患者中阻塞性睡眠呼吸暂停的诊断不足。睡眠问题，包括阻塞性睡眠呼吸暂停，在抑郁症患者中很少定期评估，但它们可能是抗抑郁治疗失败的原因。阻塞性睡眠呼吸暂停与抑郁症之间关系的机制复杂，仍不清楚。尽管一些研究表明存在相互关系，但这种关系仍不明确。几种可能的病理生理机制可以解释阻塞性睡眠呼吸暂停如何导致或加重抑郁症。对阻塞性睡眠呼吸暂停与抑郁症之间关系的更多了解可能会显著提高阻塞性睡眠呼吸暂停和抑郁症的诊断准确性以及治疗效果。
