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红斑狼疮性系统性多神经根炎伴慢性炎症性脱髓鞘性多发性神经病,利妥昔单抗治疗后预后良好。

Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with systemic lupus erythematosus and good outcome with rituximab treatment.

机构信息

Department of Neurology, Hospital Español, Belgrano 2975, C1209AAB Buenos Aires, Argentina.

出版信息

Rheumatol Int. 2012 Dec;32(12):4061-3. doi: 10.1007/s00296-011-2130-5. Epub 2011 Sep 16.

DOI:10.1007/s00296-011-2130-5
PMID:21922339
Abstract

A patient with chronic inflammatory demyelinating polyradiculoneuropathy and systemic lupus erythematosus arising after rubella vaccination was initially treated with plasmapheresis, corticosteroids and intravenous immunoglobulins, with partial response. After shift to rituximab, most clinical symptoms improved markedly, emphasizing the possible role of this monoclonal antibody in conventional therapy-resistant cases.

摘要

一名慢性炎症性脱髓鞘性多发性神经病和系统性红斑狼疮患者在接种风疹疫苗后发病,最初接受了血浆置换、皮质类固醇和静脉注射免疫球蛋白治疗,部分缓解。改用利妥昔单抗后,大多数临床症状明显改善,这强调了这种单克隆抗体在常规治疗抵抗病例中的可能作用。

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本文引用的文献

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Rituximab in autoimmune hematologic diseases: not just a matter of B cells.利妥昔单抗在自身免疫性血液系统疾病中的应用:不仅仅关乎 B 细胞。
Semin Hematol. 2010 Apr;47(2):170-9. doi: 10.1053/j.seminhematol.2010.01.010.
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Recurrences, vaccinations and long-term symptoms in GBS and CIDP.格林-巴利综合征和慢性炎症性脱髓鞘性多发性神经病的复发、疫苗接种和长期症状。
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Circulating subsets and CD4(+)CD25(+) regulatory T cell function in chronic inflammatory demyelinating polyradiculoneuropathy.
利妥昔单抗作为重症神经精神性和肾脏受累的狼疮性红斑一线治疗:病例报告及文献综述
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Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy.除皮质类固醇、免疫球蛋白和血浆置换外,用于慢性炎性脱髓鞘性多发性神经根神经病的免疫调节治疗
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Rituximab in refractory chronic inflammatory demyelinating polyradiculoneuropathy: report of four cases.利妥昔单抗治疗难治性慢性炎性脱髓鞘性多发性神经根神经病:4例报告
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6
Chronic inflammatory demyelinating polyradiculoneuropathy: from bench to bedside.慢性炎症性脱髓鞘性多发性神经根神经病:从基础到临床。
Semin Neurol. 2012 Jul;32(3):187-95. doi: 10.1055/s-0032-1329194. Epub 2012 Nov 1.
慢性炎症性脱髓鞘性多发性神经病中的循环亚群和 CD4(+)CD25(+)调节性 T 细胞功能。
Autoimmunity. 2009;42(8):667-77. doi: 10.3109/08916930903140907.
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Current treatments of chronic immune-mediated demyelinating polyneuropathies.慢性免疫介导性脱髓鞘性多发性神经病的当前治疗方法。
Muscle Nerve. 2009 May;39(5):563-78. doi: 10.1002/mus.21277.
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