Department of Pediatrics, Division of Pediatric Rheumatology, Morgan Stanley Children's Hospital of New York Presbyterian, Columbia University Medical Center, New York, New York, USA.
J Allergy Clin Immunol. 2011 Feb;127(2):303-12; quiz 313-4. doi: 10.1016/j.jaci.2010.12.1087.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant clinical heterogeneity. Recent advances in our understanding of the genetic, molecular, and cellular bases of autoimmune diseases and especially SLE have led to the application of novel and targeted treatments. Although many treatment modalities are effective in lupus-prone mice, the situation is more complex in human subjects. This article reviews the general approach to the therapy of SLE, focusing on current approved therapies and novel approaches that might be used in the future.
系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，具有显著的临床异质性。我们对自身免疫性疾病，尤其是 SLE 的遗传、分子和细胞基础的理解的最新进展，导致了新型和靶向治疗的应用。虽然许多治疗方法在狼疮易感小鼠中是有效的，但在人类受试者中情况更为复杂。本文综述了 SLE 治疗的一般方法，重点介绍了目前批准的治疗方法和未来可能使用的新方法。
