Department of Pediatrics, University of Illinois College of Medicine at Peoria, Peoria, Illinois 61637, USA.
Pediatr Blood Cancer. 2012 Aug;59(2):323-5. doi: 10.1002/pbc.23297. Epub 2011 Sep 15.
Chordomas are rare bone tumors of notochord remnants that may occur anywhere within the axial skeleton. The standard of care is complete surgical removal. Proton beam irradiation is commonly used when the tumor is inaccessible or has recurred. Chemotherapy has been used in the treatment of patients at relapse but it has been generally proven ineffective. We report a 7-month-old infant with a clival chordoma who responded to combination chemotherapy consisting of cycles of vincristine/cyclophosphamide/doxorubicin alternating with etoposide/ifosfamide. She has been off chemotherapy for 2 years and is well at age 5.
脊索瘤是源自脊索残余的罕见骨肿瘤，可发生于轴性骨骼的任何部位。标准治疗方法是完全手术切除。当肿瘤无法触及或已复发时，通常采用质子束照射。化疗已用于复发患者的治疗，但总体上已被证明无效。我们报告了一例 7 月龄婴儿的颅底脊索瘤，该患者对包含长春新碱/环磷酰胺/多柔比星与依托泊苷/异环磷酰胺交替周期的联合化疗有反应。她已停止化疗 2 年，5 岁时情况良好。
