DACTIM-MIS, Laboratory of Mathematics and Applications (LMA), UMR CNRS 7348, University of Poitiers, CHU de Poitiers, 86021 Poitiers, France.
Centre de Recherche Clinique, Grand Hôpital de l'Est Francilien (GHEF), 77100 Meaux, France.
Cells. 2020 Jan 28;9(2):314. doi: 10.3390/cells9020314.
Parkinson's disease (PD) is one of the main neurodegenerative disease characterized by a progressive degeneration of neurons constituted by dopamine in the substantia nigra pars compacta. The etiologies of PD remain unclear. Aging is the main risk factor for PD. Aging could dysregulate molecular pathways controlling cell homeostatic mechanisms. PD cells are the sites of several metabolic abnormalities including neuroinflammation and oxidative stress. Metabolic structures are driven by circadian rhythms. Biologic rhythms are complex systems interacting with the environment and controlling several physiological pathways. Recent findings have shown that the dysregulation of the circadian rhythms is correlated with PD and its metabolic dysregulations. This review is focused on the key role of circadian rhythms and their impact on neuroinflammation and oxidative stress in Parkinson's disease.
帕金森病（PD）是一种主要的神经退行性疾病，其特征是黑质致密部多巴胺能神经元进行性退化。PD 的病因仍不清楚。衰老是 PD 的主要危险因素。衰老会使控制细胞内稳态机制的分子途径失调。PD 细胞存在几种代谢异常，包括神经炎症和氧化应激。代谢结构受昼夜节律控制。生物节律是与环境相互作用并控制多种生理途径的复杂系统。最近的研究结果表明，昼夜节律失调与 PD 及其代谢失调有关。这篇综述重点介绍了昼夜节律及其对帕金森病神经炎症和氧化应激的关键作用。
