Maréchal Amandine, Meunier Brigitte, Lee David, Orengo Christine, Rich Peter R
Institute of Structural and Molecular Biology, University College, London, UK.
Biochim Biophys Acta. 2012 Apr;1817(4):620-8. doi: 10.1016/j.bbabio.2011.08.011. Epub 2011 Sep 7.
The known subunits of yeast mitochondrial cytochrome c oxidase are reviewed. The structures of all eleven of its subunits are explored by building homology models based on the published structures of the homologous bovine subunits and similarities and differences are highlighted, particularly of the core functional subunit I. Yeast genetic techniques to enable introduction of mutations into the three core mitochondrially-encoded subunits are reviewed.
本文综述了酵母线粒体细胞色素c氧化酶的已知亚基。基于同源牛亚基的已发表结构构建同源模型，对其全部11个亚基的结构进行了探索，并突出了它们的异同，特别是核心功能亚基I。本文还综述了利用酵母遗传技术将突变引入三个线粒体编码的核心亚基的方法。
