Weismann K, Jakobsen J P, Weismann J E, Hammer U M, Nyholm S M, Hansen B, Lomholt K E, Schmidt K
Department of Dermatology, Bispebjerg Hospital, Copenhagen.
Dan Med Bull. 1990 Jun;37(3):279-81.
In a double-blind clinical trial, a total of 463 volunteers were enrolled in a study designed to compare the effects of zinc gluconate lozenges (4.5 mg zinc) and a placebo for common cold. The tablets were to be taken every 1-1 1/2 waking hours at the first symptoms and for the following days until the common cold was over, but for no longer than 10 days. During the winter months of 1987 and 1988, 145 experienced a common cold and 130 completed the study. For final analysis, 61 patients in the zinc lozenge group and 69 patients in the placebo lozenge group were evaluated. Based on the patients' records the duration and severity of the common cold were compared. No statistically significant differences were found between the patient groups. Two recent studies using a five-time higher zinc dose per lozenge for common cold showed a significant, positive effect, but associated with frequent side-effects, first of all taste distortion. In the present study there was a weak tendency (not statistically significant, p = 0.12) towards more patients in the zinc lozenge group than in the placebo lozenge group reporting side-effects.
在一项双盲临床试验中，共有463名志愿者参与了一项旨在比较葡萄糖酸锌含片（含4.5毫克锌）和安慰剂对普通感冒疗效的研究。在出现最初症状时，每1至1个半小时服用一片含片，随后几天持续服用，直至普通感冒痊愈，但服用时间不超过10天。在1987年和1988年的冬季，145人患了普通感冒，其中130人完成了研究。为进行最终分析，对葡萄糖酸锌含片组的61名患者和安慰剂含片组的69名患者进行了评估。根据患者记录，比较了普通感冒的持续时间和严重程度。两组患者之间未发现统计学上的显著差异。最近两项针对普通感冒使用每片含锌量高出五倍的含片的研究显示出显著的积极效果，但伴有频繁的副作用，首先是味觉失真。在本研究中，葡萄糖酸锌含片组报告有副作用的患者比安慰剂含片组略多（无统计学意义，p = 0.12）。
