State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China.
Nutr Metab Cardiovasc Dis. 2011 Nov;21(11):844-50. doi: 10.1016/j.numecd.2011.04.008. Epub 2011 Sep 17.
Human clinical studies have yielded mixed results on the effects of consumption of probiotics on the plasma lipid profile. We conducted a meta-analysis of randomised controlled trials that evaluated the effects of probiotics consumption on blood lipids.
A systematic literature search of Embase, Web of Science, PubMed and Cochrane Controlled Trials Registry was conducted for studies that investigated the efficacy of probiotics on the plasma lipid profile of subjects. With the help of Review Manager 4.2, data from 13 trials, which included 485 participants with high, borderline high and normal cholesterol levels, were examined. The pooled mean net change in total cholesterol for those treated with probiotics compared to controls was -6.40 mg dl(-1) (95% confidence interval (CI), -9.93 to -2.87), mean net change in low-density lipoprotein (LDL) cholesterol was -4.90 mg dl(-1) (95% CI, -7.91 to -1.90), mean net change in high-density lipoprotein (HDL) cholesterol was -0.11 mg dl(-1) (95% CI, -1.90-1.69) and mean net change in triglycerides was -3.95 mg dl(-1) (95% CI, -10.32-2.42).
These results indicate that a diet rich in probiotics decreases total cholesterol and LDL cholesterol concentration in plasma for participants with high, borderline high and normal cholesterol levels.
人体临床研究对于益生菌消耗对血浆脂质谱的影响得出了混合的结果。我们对评估益生菌消耗对血脂影响的随机对照试验进行了荟萃分析。
对 Embase、Web of Science、PubMed 和 Cochrane 对照试验登记处进行了系统的文献检索，以寻找研究益生菌对受试者血浆脂质谱影响的研究。借助 Review Manager 4.2，检查了 13 项试验的数据，这些试验共包括 485 名高、边缘高和正常胆固醇水平的参与者。与对照组相比，用益生菌治疗的患者的总胆固醇的净变化平均值为-6.40mg/dl（95%置信区间（CI），-9.93 至-2.87），低密度脂蛋白（LDL）胆固醇的净变化平均值为-4.90mg/dl（95%CI，-7.91 至-1.90），高密度脂蛋白（HDL）胆固醇的净变化平均值为-0.11mg/dl（95%CI，-1.90-1.69），甘油三酯的净变化平均值为-3.95mg/dl（95%CI，-10.32-2.42）。
这些结果表明，富含益生菌的饮食可降低高、边缘高和正常胆固醇水平参与者血浆中的总胆固醇和 LDL 胆固醇浓度。
