Khalafi Mousa, Dinizadeh Farnaz, Rosenkranz Sara K, Symonds Michael E, Fatolahi Saeid
Department of Sport Sciences, Faculty of Humanities, University of Kashan, Kashan 87317-53153, Iran.
Department of Sport Sciences, Tabriz Branch, Azad University, Tabriz 51579-44533, Iran.
Healthcare (Basel). 2025 Jan 26;13(3):246. doi: 10.3390/healthcare13030246.
We performed a systematic review and meta-analysis to investigate the effects of exercise training on body composition and cardiometabolic health in patients with Type 1 diabetes (T1D).
A search in three main databases including PubMed, Web of Science, and Scopus was conducted from the inception of this review until June 2024 to identify randomized control trials investigating the effects of exercise training compared to a control on body composition and cardiometabolic risk factors in patients with T1D. The data were pooled using random effects models to calculate weighted mean differences (WMDs), standardized mean differences (SMDs), and 95% confidence intervals (CIs).
Overall, 25 studies involving 1120 patients with T1D were included in the meta-analysis. Exercise training decreased body mass index (BMI) [WMD: -0.18 kg.m, = 0.02], fasting glucose [WMD: -14.97 mg/dl, = 0.01], and HbA1c [WMD: -0.49%, = 0.003], and increased VO [WMD: 2.76 mL/kg/min, = 0.001] as compared with controls. Exercise training had no effect on body fat percentage or lean body mass, lipid profiles, or blood pressure. Subgroup analysis indicated that age, exercise mode, and intervention duration were the main moderators for the beneficial effects of exercise training.
In patients with T1D, exercise training is effective for decreasing body weight and cardiometabolic risk factors.
我们进行了一项系统综述和荟萃分析，以研究运动训练对1型糖尿病（T1D）患者身体成分和心脏代谢健康的影响。
从本综述开始至2024年6月，在包括PubMed、科学网和Scopus在内的三个主要数据库中进行检索，以识别研究运动训练与对照组相比对T1D患者身体成分和心脏代谢危险因素影响的随机对照试验。使用随机效应模型汇总数据，以计算加权平均差（WMD）、标准化平均差（SMD）和95%置信区间（CI）。
总体而言，荟萃分析纳入了25项涉及1120例T1D患者的研究。与对照组相比，运动训练降低了体重指数（BMI）[WMD：-0.18kg·m²，P = 0.02]、空腹血糖[WMD：-14.97mg/dl，P = 0.01]和糖化血红蛋白（HbA1c）[WMD：-0.49%，P = 0.003]，并提高了最大摄氧量（VO₂）[WMD：2.76mL/kg/min，P = 0.001]。运动训练对体脂百分比、瘦体重、血脂谱或血压没有影响。亚组分析表明，年龄、运动模式和干预持续时间是运动训练有益效果的主要调节因素。
在T1D患者中，运动训练对减轻体重和降低心脏代谢危险因素有效。
