基于家庭的行为治疗在英国国民保健制度环境下治疗儿童肥胖症：随机对照试验。
Family-based behavioural treatment of childhood obesity in a UK National Health Service setting: randomized controlled trial.
机构信息
Department of Epidemiology and Public Health, Cancer Research UK Health Behaviour Research Centre, UCL, London, UK.
出版信息
Int J Obes (Lond). 2012 Jan;36(1):16-26. doi: 10.1038/ijo.2011.182. Epub 2011 Sep 20.
BACKGROUND
The best outcomes for treating childhood obesity have come from comprehensive family-based programmes. However there are questions over their generalizability.
OBJECTIVE
To examine the acceptability and effectiveness of 'family-based behavioural treatment' (FBBT) for childhood obesity in an ethnically and socially diverse sample of families in a UK National Health Service (NHS) setting.
METHODS
In this parallel group, randomized controlled trial, 72 obese children were randomized to FBBT or a waiting-list control. Primary outcomes were body mass index (BMI) and BMI s.d. scores (SDSs). Secondary outcomes were weight, weight SDSs, height, height SDSs, waist, waist SDSs, FM index, FFM index, blood pressure (BP) and psychosocial measures. The outcomes were assessed at baseline and after treatment, with analyses of 6-month data performed on an intent-to-treat (ITT) basis. Follow-up anthropometric data were collected at 12 months for the treatment group.
RESULTS
ITT analyses included all children with baseline data (n=60). There were significant BMI SDS changes (P<0.01) for the treatment and control groups of -0.11 (0.16) and -0.10 (1.6). The treatment group showed a significant reduction in systolic BP (-0.24 (0.7), P<0.05) and improvements in quality of life and eating attitudes (P<0.05), with no significant changes for the control group. However the between-group treatment effects for BMI, body composition, BP and psychosocial outcomes were not significant. There was no overall change in BMI or BMI SDSs from 0-12 months for the treatment group. No adverse effects were reported.
CONCLUSIONS
Both treatment and control groups experienced significant reductions in the level of overweight, but with no significant difference between them. There were no significant group differences for any of the secondary outcomes. This trial was registered at http://www.controlled-trials.com/ under ISRCTN 51382628.
背景
治疗儿童肥胖症的最佳结果来自于综合的家庭为基础的方案。然而，人们对这些方案的普遍性存在疑问。
目的
在英国国民保健服务（NHS）环境中，对具有不同种族和社会背景的家庭进行基于家庭的行为治疗（FBBT）治疗儿童肥胖症的可接受性和有效性进行研究。
方法
在这项平行组、随机对照试验中，72 名肥胖儿童被随机分配到 FBBT 组或等候名单对照组。主要结局是体重指数（BMI）和 BMI 标准差评分（SDS）。次要结局是体重、体重 SDS、身高、身高 SDS、腰围、腰围 SDS、FM 指数、FFM 指数、血压（BP）和心理社会测量。在基线和治疗后评估这些结局，并对意向治疗（ITT）进行 6 个月数据分析。治疗组在 12 个月时收集随访人体测量数据。
结果
ITT 分析包括所有有基线数据的儿童（n=60）。治疗组和对照组的 BMI SDS 均有显著变化（P<0.01），分别为-0.11（0.16）和-0.10（1.6）。治疗组收缩压显著降低（-0.24（0.7），P<0.05），生活质量和饮食态度改善（P<0.05），对照组无显著变化。然而，BMI、身体成分、BP 和心理社会结局的组间治疗效果不显著。治疗组从 0 到 12 个月 BMI 或 BMI SDS 没有总体变化。没有报告不良反应。
结论
治疗组和对照组的超重水平都显著降低，但两组之间没有显著差异。次要结局没有显著的组间差异。这项试验在 http://www.controlled-trials.com/ 上注册，注册号为 ISRCTN 51382628。
Zotero 插件