Center of Excellence in Nanotechnology, Asian Institute of Technology, Klong Luang, Pathumthani, 12120, Thailand.
J Fluoresc. 2012 Jan;22(1):403-8. doi: 10.1007/s10895-011-0973-5. Epub 2011 Sep 20.
A novel biocompatible chitosan passivated manganese doped zinc sulfide (Mn doped ZnS) nanophosphor has been synthesized through a simple aqueous precipitation reaction. Upon excitation with ultraviolet light, the quantum dots (QDs) emit an orange luminescence peaking at 590 nm, which is visible to the naked eye. These chitosan coated Mn doped ZnS QDs can have potential applications in bio-labeling, particularly in fluorescence-based imaging. One of the envisioned applications of these QDs is in improving the conventional, organic dye-reliant Fluorescence in situ Hybridization (FISH) technique, a widely used method for microbial detection. Here we demonstrate that the chitosan-capped Mn doped ZnS QDs are suitable for this purpose.
一种新型的生物相容性壳聚糖钝化的锰掺杂硫化锌（Mn 掺杂 ZnS）纳米荧光粉通过简单的水相沉淀反应合成。在紫外光激发下，量子点（QDs）发出峰值在 590nm 的橙色荧光，肉眼可见。这些壳聚糖包覆的 Mn 掺杂 ZnS QDs 可在生物标记中具有潜在的应用，特别是在基于荧光的成像中。这些 QDs 的预期应用之一是改进传统的、依赖有机染料的荧光原位杂交（FISH）技术，这是一种广泛用于微生物检测的方法。在这里，我们证明了壳聚糖封端的 Mn 掺杂 ZnS QDs 非常适合这种用途。
