Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them.
作者信息
Varki Ajit
出版信息
Glycobiology. 2011 Sep;21(9):1121-4. doi: 10.1093/glycob/cwr087.
Abstract
摘要
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Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them.既然存在病原体相关分子模式（PAMPs）和损伤相关分子模式（DAMPs），那么必然也存在自身相关分子模式（SAMPs）？聚糖“自身相关分子模式”会抑制先天性免疫，但病原体可以对其进行模仿。
Glycobiology. 2011 Sep;21(9):1121-4. doi: 10.1093/glycob/cwr087.
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本文引用的文献
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Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.补体通过因子 H 与 C3d 和糖胺聚糖的双重相互作用进行宿主-非宿主识别。
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Hyaluronan as an immune regulator in human diseases.透明质酸作为人类疾病中的免疫调节剂。
Physiol Rev. 2011 Jan;91(1):221-64. doi: 10.1152/physrev.00052.2009.
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The inflammasome NLRs in immunity, inflammation, and associated diseases.炎性体 NLR 家族在免疫、炎症及相关疾病中的作用
Annu Rev Immunol. 2011;29:707-35. doi: 10.1146/annurev-immunol-031210-101405.
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Sterile inflammation: sensing and reacting to damage.无菌性炎症：感知和应对损伤。
Nat Rev Immunol. 2010 Dec;10(12):826-37. doi: 10.1038/nri2873. Epub 2010 Nov 19.
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The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis.蛋白聚糖 biglycan 调节 B 细胞趋化因子 CXCL13 的表达，并加重小鼠狼疮肾炎。
J Clin Invest. 2010 Dec;120(12):4251-72. doi: 10.1172/JCI42213. Epub 2010 Nov 15.
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Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?CD33 相关 Siglecs 的进化：调节宿主免疫功能并逃避病原体利用？
Immunology. 2011 Jan;132(1):18-26. doi: 10.1111/j.1365-2567.2010.03368.x. Epub 2010 Nov 11.
8
Colloquium paper: uniquely human evolution of sialic acid genetics and biology.学术研讨会论文：唾液酸遗传学和生物学的独特人类进化。
Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2(Suppl 2):8939-46. doi: 10.1073/pnas.0914634107. Epub 2010 May 5.
9
Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.正常小鼠肺部 Siglec-F 糖结合配体表达的特征。
Am J Respir Cell Mol Biol. 2011 Feb;44(2):238-43. doi: 10.1165/rcmb.2010-0007OC. Epub 2010 Apr 15.
10
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.唾液酸结合免疫球蛋白样凝集素 8（Siglec-8）基因多态性与哮喘易感性相关。
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