Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA.
Ann N Y Acad Sci. 2012 Apr;1253(1):37-48. doi: 10.1111/j.1749-6632.2011.06362.x. Epub 2012 Jan 30.
Siglecs are expressed on most white blood cells of the immune system and are known to modulate the activity of cell signaling receptors via regulatory motifs in their cytoplasmic domains. This immunoglobulin subfamily of coreceptors recognize sialic acid containing glycans as ligands, which are found on glycoproteins and glycolipids of all mammalian cells. By virtue of their ability to recognize this common structural element, siglecs are increasingly recognized for their ability to help immune cells distinguish between self and nonself, and dampen autoimmune responses.
Siglecs 表达于免疫系统的大多数白细胞上，并且已知通过其细胞质结构域中的调节基序来调节细胞信号转导受体的活性。 作为配体，该免疫球蛋白亚家族的共受体识别含有唾液酸的聚糖，这些聚糖存在于所有哺乳动物细胞的糖蛋白和糖脂上。 由于其识别这种共同结构元素的能力，Siglecs 越来越被认为能够帮助免疫细胞区分自我和非自我，并抑制自身免疫反应。
