Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Diabetes Care. 2011 Nov;34(11):2393-9. doi: 10.2337/dc11-0876. Epub 2011 Sep 20.
To test the association of family history of diabetes with the adoption of diabetes risk-reducing behaviors and whether this association is strengthened by physician advice or commonly known factors associated with diabetes risk.
We used cross-sectional data from the 2005-2008 National Health and Nutrition Examination Survey (NHANES) to examine the effects of family history of diabetes on the adoption of selected risk-reducing behaviors in 8,598 adults (aged ≥20 years) without diabetes. We used multiple logistic regression to model three risk reduction behaviors (controlling or losing weight, increasing physical activity, and reducing the amount of dietary fat or calories) with family history of diabetes.
Overall, 36.2% of U.S. adults without diabetes had a family history of diabetes. Among them, ~39.8% reported receiving advice from a physician during the past year regarding any of the three selected behaviors compared with 29.2% of participants with no family history (P < 0.01). In univariate analysis, adults with a family history of diabetes were more likely to perform these risk-reducing behaviors compared with adults without a family history. Physician advice was strongly associated with each of the behavioral changes (P < 0.01), and this did not differ by family history of diabetes.
Familial risk for diabetes and physician advice both independently influence the adoption of diabetes risk-reducing behaviors. However, fewer than half of participants with familial risk reported receiving physician advice for adopting these behaviors.
检验糖尿病家族史与采取降低糖尿病风险行为之间的关联，以及这种关联是否因医生建议或与糖尿病风险相关的常见因素而增强。
我们使用 2005-2008 年全国健康和营养调查（NHANES）的横断面数据，在 8598 名无糖尿病的成年人（年龄≥20 岁）中研究糖尿病家族史对特定降低风险行为的影响。我们使用多因素逻辑回归模型来研究三种降低风险行为（控制或减轻体重、增加身体活动和减少饮食中的脂肪或热量）与糖尿病家族史的关系。
总体而言，36.2%的无糖尿病美国成年人有糖尿病家族史。其中，约 39.8%的人在过去一年中收到过医生关于三种选定行为中任何一种的建议，而无家族史的参与者中这一比例为 29.2%（P<0.01）。在单因素分析中，有糖尿病家族史的成年人比没有家族史的成年人更有可能采取这些降低风险的行为。医生的建议与每种行为的改变都有很强的相关性（P<0.01），而且与糖尿病家族史无关。
糖尿病的家族风险和医生建议都独立地影响着降低糖尿病风险行为的采取。然而，只有不到一半的有家族风险的参与者报告说他们接受过医生关于采取这些行为的建议。
