Rao Shalinee, Sadiya N, Joseph Leena Dennis, Rajendiran S
Department of Pathology, Sri Ramachandra University, Porur, Chennai - 600 116, India.
J Cytol. 2009 Jan;26(1):26-9. doi: 10.4103/0970-9371.54864.
The present study was done to evaluate the role of scrape cytology in the diagnosis of ovarian neoplasm and its utilization for teaching pathology residents.
This was a prospective study on 50 solid/solid-cystic ovarian neoplasms sent in 10% buffered formalin. Scrapings obtained from the fresh cut surface of tumors were smeared uniformly on to glass slides, immediately fixed in 95% ethyl alcohol and stained with hematoxylin and eosin stain.
The overall diagnostic accuracy of scrape cytology has been satisfactory with 92% of cases correlating with the final diagnosis. Characteristic cytological pattern was noted in various types of surface epithelial, sex cord stromal and germ cell tumors. The technique had limited value in mucinous tumors to distinguish borderline cases from invasive carcinoma. Two mucinous carcinomas were diagnosed as borderline mucinous tumor and two endometrioid carcinomas were misinterpreted as cystadenocarcinoma on scrape cytology. Formalin did not interfere or produce any remarkable changes in cytomorphology.
Scrape cytology is a simple, rapid, accurate, inexpensive adjunctive cytodiagnostic technique and its routine utilization in ovarian lesions could aid in expanding the cytological knowledge of ovarian neoplasms.
本研究旨在评估刮片细胞学在卵巢肿瘤诊断中的作用及其在病理学住院医师教学中的应用。
这是一项对50例实性/实性囊性卵巢肿瘤进行的前瞻性研究，肿瘤用10%中性福尔马林固定。从肿瘤新鲜切面获取的刮片均匀涂抹在载玻片上，立即用95%乙醇固定，并用苏木精和伊红染色。
刮片细胞学的总体诊断准确性令人满意，92%的病例与最终诊断相符。在各种类型的表面上皮性、性索间质和生殖细胞肿瘤中观察到特征性的细胞学模式。该技术在黏液性肿瘤中区分交界性病例和浸润性癌的价值有限。在刮片细胞学检查中，有2例黏液性癌被诊断为交界性黏液性肿瘤，2例子宫内膜样癌被误诊为囊腺癌。福尔马林未干扰细胞形态学或产生任何显著变化。
刮片细胞学是一种简单、快速、准确、廉价的辅助细胞诊断技术，在卵巢病变中的常规应用有助于扩大对卵巢肿瘤的细胞学认识。
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