Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid Spain.
Clin Biochem. 2011 Nov;44(16):1280-3. doi: 10.1016/j.clinbiochem.2011.09.002. Epub 2011 Sep 16.
As unclear data of resistin relation with metabolic syndrome has been published, we decide to investigate the association between metabolic syndrome and resistin levels in female obese subjects.
A sample of 551 female obese subjects was analyzed. A complete nutritional and biochemical evaluation was performed.
Levels of C reactive protein, weight, fat mass and waist circumference were higher in patients in the highest tertile group of resistin than the lowest and middle tertiles of resistin. In the multivariate analysis with metabolic syndrome presence/absence-, only fat mass remained as an independent predictor in the model. Resistin concentration increases 0.020 ng/ml (CI95%:0.006-0.038) for each kg of fat mass in female obese subjects.
Only fat mass was associated in an independent way. Serum resistin was not associated with the accumulation of MetS factors or the diagnosis of MetS in obese female subjects.
由于关于抵抗素与代谢综合征关系的数据尚不清楚，我们决定研究代谢综合征与肥胖女性抵抗素水平之间的关系。
分析了 551 名肥胖女性受试者的样本。进行了全面的营养和生化评估。
抵抗素水平最高三分位组的患者的 C 反应蛋白、体重、脂肪量和腰围均高于抵抗素水平最低和中位三分位组的患者。在以代谢综合征存在/缺失为因变量的多变量分析中，只有脂肪量仍然是模型中的独立预测因子。肥胖女性受试者的脂肪量每增加 1 公斤，抵抗素浓度增加 0.020 纳克/毫升（95%置信区间：0.006-0.038）。
只有脂肪量与抵抗素有独立的关联。血清抵抗素与肥胖女性代谢综合征因素的积累或代谢综合征的诊断无关。
