Committee on Immunology, The University of Chicago, Chicago, IL, USA.
Trends Immunol. 2011 Nov;32(11):524-31. doi: 10.1016/j.it.2011.08.007. Epub 2011 Sep 21.
Since its first administration in the 1940s, the influenza vaccine has provided tremendous relief against influenza infections. However, time has revealed the ultimate limit of the vaccine and the call for its reinvention has now come, just as we are beginning to appreciate the antibody immune responses vital in preventing infections. New strategies to design the influenza vaccine rely on selectively inducing broadly neutralizing antibodies that are specific for highly conserved viral epitopes. Such approaches take us away from the limited range of protection provided by current seasonal influenza vaccines and towards a future with a pan-influenza vaccine capable of providing universal strain coverage.
自 20 世纪 40 年代首次使用以来，流感疫苗在防治流感感染方面发挥了巨大作用。然而，时间已经揭示了疫苗的最终局限性，现在人们呼吁对其进行重新设计，就像我们开始认识到预防感染至关重要的抗体免疫反应一样。设计流感疫苗的新策略依赖于选择性诱导针对高度保守病毒表位的广泛中和抗体。这些方法使我们摆脱了当前季节性流感疫苗提供的有限保护范围，走向了能够提供通用菌株覆盖的泛流感疫苗的未来。
