Igari J, Shitara M, Shitara M, Yoshimoto K, Hayashi Y, Suzuki A, Kudo H, Hayasaka N, Toyoshima S, Yamazaki Y
Department of Clinical Pathology, School of Health Science Faculty of Medicine, University of the Ryukyus.
Jpn J Antibiot. 1990 Feb;43(2):362-73.
A nationwide survey of susceptibilities of Staphylococcus aureus, Escherichia coli, Klebsiella sp. and Proteus mirabilis initiated in 1980 was continued in 1986. This report documents differences in susceptibilities of clinical isolates of the above microorganisms to ampicillin (ABPC), cefazolin (CEZ), cefmetazole (CMZ) and gentamicin (GM) among general hospitals throughout Japan. Clinical isolates of each species of microorganisms which were collected in 24 hospitals made up each study group and were collected at the Kosei General Hospital, Tokyo, from April 1980 to March 1986. We compared the variability in the resistant rates (MIC greater than or equal to 25 micrograms/ml) and MICs of each antibiotic for 50% and 80% of the isolates among the hospitals. MICs were determined by the serial 2 fold agar plate dilution method, standardized by the Japan Society of Chemotherapy, with an inoculum of approximately 10(6) CFU/ml or 10(8) CFU/ml. Susceptibility patterns of S. aureus to ABPC, CEZ and GM, of E. coli to ABPC, of Klebsiella sp. to CEZ and GM and of P. mirabilis to ABPC, CEZ and GM varied from hospital to hospital. On the other hand, the differences in the susceptibility patterns among the 6 districts of Japan were not obvious, because the differences were affected by different susceptibility patterns of each hospital located in each district.
1980年开始的一项关于金黄色葡萄球菌、大肠杆菌、克雷伯菌属和奇异变形杆菌药敏情况的全国性调查于1986年继续进行。本报告记录了日本各地综合医院中上述微生物临床分离株对氨苄西林（ABPC）、头孢唑林（CEZ）、头孢美唑（CMZ）和庆大霉素（GM）的药敏差异。在24家医院收集的每种微生物的临床分离株组成了每个研究组，这些分离株于1980年4月至1986年3月在东京的厚生综合医院收集。我们比较了各医院中每种抗生素对50%和80%分离株的耐药率（MIC大于或等于25微克/毫升）和MIC的变异性。MIC采用日本化疗学会标准化的连续2倍琼脂平板稀释法测定，接种量约为10（6）CFU/毫升或10（8）CFU/毫升。金黄色葡萄球菌对ABPC、CEZ和GM的药敏模式，大肠杆菌对ABPC的药敏模式，克雷伯菌属对CEZ和GM的药敏模式，以及奇异变形杆菌对ABPC、CEZ和GM的药敏模式因医院而异。另一方面，日本6个地区之间药敏模式的差异并不明显，因为这些差异受到每个地区各医院不同药敏模式的影响。
