Igari J, Shitara M, Morimoto M, Shiga N, Kosakai N
Jpn J Antibiot. 1986 Nov;39(11):3110-24.
We have reported the antimicrobial susceptibility of clinical isolates of Escherichia coli in 1983 and 1984 to 4 antibiotics, ampicillin (ABPC), cefazolin (CEZ), cefmetazole (CMZ) and gentamicin (GM), in the previous report. In this paper, we described the antimicrobial susceptibility of Klebsiella sp. to the same antibiotics during the same period reported for E. coli before. Numbers of isolates tested were 1,671 strains in 1983 and 1,374 strains in 1984. We determined MICs of the 4 antibiotics against isolates by the standard method of the Japan Society of Chemotherapy. The most effective agent was GM among the 4 antibiotics. CMZ had a similar antimicrobial activity to GM. Resistance rates were low for both agents. CEZ had a fairly good antimicrobial activity, but it was less active than GM and CMZ. ABPC was not effective. There was neither significant annual change of antimicrobial activity of each agent against isolates nor an increasing tendency of resistant strains in the last 5 years. Depending on isolates from clinical materials, differences in the susceptibility were noted and there was a high ratio of resistant organisms among isolates from urine.
我们曾在上一篇报告中报道了1983年和1984年大肠杆菌临床分离株对4种抗生素，即氨苄西林（ABPC）、头孢唑林（CEZ）、头孢美唑（CMZ）和庆大霉素（GM）的药敏情况。在本文中，我们描述了肺炎克雷伯菌属在与之前报道的大肠杆菌相同时期对相同抗生素的药敏情况。1983年测试的分离株数量为1671株，1984年为1374株。我们采用日本化疗学会的标准方法测定了这4种抗生素对分离株的最低抑菌浓度（MIC）。在这4种抗生素中，最有效的药物是GM。CMZ具有与GM相似的抗菌活性。两种药物的耐药率都很低。CEZ具有相当好的抗菌活性，但比GM和CMZ的活性低。ABPC无效。在过去5年中，每种药物对分离株的抗菌活性既没有显著的年度变化，耐药菌株也没有增加的趋势。根据临床材料的分离株，发现药敏存在差异，尿液分离株中的耐药菌比例很高。
