Henry Wellcome Laboratory of Cell Biology, Davidson Building, Institute for Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
J Cell Sci. 2011 Oct 1;124(Pt 19):3199-207. doi: 10.1242/jcs.083949.
The terminal stage of cytokinesis - a process termed abscission - is the severing of the thin intercellular bridge that connects the two daughter cells. Recent work provides new insight into the mechanism by which this microtubule-dense membrane bridge is resolved, and highlights important roles for multi-protein assemblies in different facets of abscission. These include the endosomal sorting complex required for transport (ESCRT), which appears to have a decisive role in the final scission event, and vesicle tethering complexes, which potentially act at an earlier stage, and might serve to prepare the abscission site. Here, we review recent studies of the structure, function and regulation of these complexes as related to abscission. We focus largely on studies of cytokinesis in mammalian cells. However, cell division in other systems, such as plants and Archae, is also considered, reflecting the mechanistic conservation of membrane-scission processes during cell division.
有丝分裂末期——这个过程被称为胞质分裂——是切断连接两个子细胞的细细胞间桥的过程。最近的研究工作为理解微管密集的膜桥如何被解决提供了新的见解，并强调了多蛋白复合物在胞质分裂不同方面的重要作用。其中包括内体分选复合物需要运输（ESCRT），它似乎在最后的分裂事件中具有决定性作用，以及囊泡连接复合物，它们可能在早期阶段发挥作用，并可能有助于准备胞质分裂位点。在这里，我们回顾了最近关于这些复合物的结构、功能和调节的研究，这些研究与胞质分裂有关。我们主要关注哺乳动物细胞有丝分裂的研究。然而，其他系统（如植物和古菌）的细胞分裂也被考虑在内，反映了细胞分裂过程中膜分裂过程的机制保守性。
