Aprahamian Tamar R, Sam Flora
Renal Section, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Int J Inflam. 2011;2011:376909. doi: 10.4061/2011/376909. Epub 2011 Sep 15.
Inflammation is widely known to play a key role in the development and progression of cardiovascular diseases. It is becoming increasingly evident that obesity is linked to many proinflammatory and obesity-associated cardiovascular conditions (e.g., metabolic syndrome, acute coronary syndrome, and congestive heart failure). It has been observed that adipokines play an increasingly large role in systemic and local inflammation. Therefore, adipose tissue may have a more important role than previously thought in the pathogenesis of several disease types. This review explores the recently described role of adiponectin as an immunomodulatory factor and how it intersects with the inflammation associated with both cardiovascular and autoimmune pathologies.
众所周知，炎症在心血管疾病的发生和发展中起着关键作用。越来越明显的是，肥胖与许多促炎和肥胖相关的心血管疾病（如代谢综合征、急性冠状动脉综合征和充血性心力衰竭）有关。据观察，脂肪因子在全身和局部炎症中发挥着越来越大的作用。因此，脂肪组织在几种疾病类型的发病机制中可能具有比以前认为的更重要的作用。本综述探讨了脂联素作为一种免疫调节因子最近所描述的作用，以及它如何与心血管和自身免疫性疾病相关的炎症相互作用。
